UniProt A5U8D3
DNA-directed RNA polymerase subunit alpha (A5U8D3)
DNA-directed RNA polymerase subunit alpha (UniProt A5U8D3), EC 2.7.7.6: 34 experimental structures and 1 predicted model on GenesisL1, 64 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- A5U8D3
- Protein
- DNA-directed RNA polymerase subunit alpha
- EC
- 2.7.7.6
- Experimental structures
- 34
- Predicted models
- 1
- Pockets
- 64 · 16 records with a druggable one
Structures
35 records of A5U8D3 in the MolNFT archive: 34 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6EDT | Mycobacterium tuberculosis RNAP open promoter complex with RbpA/CarD and AP3 promoter | electron microscopy | A, B | — | 4 (best 0.82) |
| 6EDT | Mycobacterium tuberculosis rnap open promoter complex with RBPA/CARD and AP3 promoter | electron microscopy | A, B | — | — |
| 6EE8 | Mycobacterium tuberculosis RNAP promoter unwinding intermediate complex with RbpA/CarD and AP3… | electron microscopy | A, B | — | 5 (best 0.81) |
| 6EE8 | Mycobacterium tuberculosis rnap promoter unwinding intermediate complex with RBPA/CARD and AP3… | electron microscopy | A, B | — | — |
| 6EEC | Mycobacterium tuberculosis RNAP promoter unwinding intermediate complex with RbpA/CarD and AP3… | electron microscopy | A, B | — | 5 (best 0.82) |
| 6EEC | Mycobacterium tuberculosis rnap promoter unwinding intermediate complex with RBPA/CARD and AP3… | electron microscopy | A, B | — | — |
| 6M7J | Mycobacterium tuberculosis RNAP with RbpA/us fork and Corallopyronin | electron microscopy | A, B | — | — |
| 6M7J | Mycobacterium tuberculosis rnap with RBPA/US fork and corallopyronin | electron microscopy | A, B | — | — |
| 6TYE | Crystal structure of MTB sigma L transcription initiation complex with 5 nt long RNA primer | x-ray diffraction | A, B | — | — |
| 6TYE | Crystal structure of mtb sigma L transcription initiation complex with 5 nt long RNA primer | x-ray diffraction | A, B | — | — |
| 6TYF | Crystal structure of MTB sigma L transcription initiation complex with 6 nt long RNA primer | x-ray diffraction | A, B | — | 6 (best 0.80) |
| 6TYF | Crystal structure of mtb sigma L transcription initiation complex with 6 nt long RNA primer | x-ray diffraction | A, B | — | — |
| 6TYG | Crystal structure of mtb sigma L transcription initiation complex with 9 nt long RNA primer | x-ray diffraction | A, B | — | — |
| 6VVX | Mycobacterium tuberculosis WT RNAP transcription initiation intermediate structure with Sorangicin | electron microscopy | A, B | — | 4 (best 0.80) |
| 6VVX | Mycobacterium tuberculosis wt rnap transcription initiation intermediate structure with sorangicin | electron microscopy | A, B | — | — |
| 6VVY | Mycobacterium tuberculosis WT RNAP transcription open promoter complex with Sorangicin | electron microscopy | A, B | — | 3 (best 0.80) |
| 6VVY | Mycobacterium tuberculosis wt rnap transcription open promoter complex with sorangicin | electron microscopy | A, B | — | — |
| 6VVZ | Mycobacterium tuberculosis RNAP S456L mutant transcription initiation intermediate structure with… | electron microscopy | A, B | — | 4 (best 0.84) |
| 6VVZ | Mycobacterium tuberculosis rnap S456L mutant transcription initiation intermediate structure with… | electron microscopy | A, B | — | — |
| 6VW0 | Mycobacterium tuberculosis RNAP S456L mutant open promoter complex | electron microscopy | A, B | — | 3 (best 0.83) |
| 6VW0 | Mycobacterium tuberculosis rnap S456L mutant open promoter complex | electron microscopy | A, B | — | — |
| 7KIF | Mycobacterium tuberculosis WT RNAP transcription open promoter complex with WhiB7 transcription… | electron microscopy | A, B | — | 3 (best 0.80) |
| 7KIF | Mycobacterium tuberculosis wt rnap transcription open promoter complex with WHIB7 transcription… | electron microscopy | A, B | — | — |
| 7KIM | Mycobacterium tuberculosis WT RNAP transcription closed promoter complex with WhiB7 transcription… | electron microscopy | A, B | — | 4 (best 0.82) |
| 7KIM | Mycobacterium tuberculosis wt rnap transcription closed promoter complex with WHIB7 transcription… | electron microscopy | A, B | — | — |
| 7KIN | Mycobacterium tuberculosis WT RNAP transcription open promoter complex with WhiB7 promoter | electron microscopy | A, B | — | 3 (best 0.83) |
| 7KIN | Mycobacterium tuberculosis wt rnap transcription open promoter complex with WHIB7 promoter | electron microscopy | A, B | — | — |
| 7RWI | Mycobacterium tuberculosis RNA polymerase sigma L holoenzyme open promoter complex containing… | x-ray diffraction | A, B | — | — |
| 7U22 | Mycobacterium tuberculosis RNA polymerase sigma A holoenzyme open promoter complex containing UMN-7 | x-ray diffraction | A, B | — | 4 (best 0.82) |
| 8E74 | Mycobacterium tuberculosis RNAP paused elongation complex with NusG transcription factor | electron microscopy | A, B | — | 5 (best 0.81) |
| 8E79 | Mycobacterium tuberculosis RNAP paused elongation complex with Escherichia coli NusG transcription… | electron microscopy | A, B | — | 5 (best 0.83) |
| 8E82 | Mycobacterium tuberculosis RNAP elongation complex with NusG transcription factor | electron microscopy | A, B | — | — |
| 8E8M | Mycobacterium tuberculosis RNAP paused elongation complex | electron microscopy | A, B | — | 5 (best 0.82) |
| 8E95 | Mycobacterium tuberculosis RNAP elongation complex | electron microscopy | A, B | — | — |
| A5U8D3 | AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit alpha (A5U8D3) | predicted | A | — | 1 (best 0.53) |
Experiment against prediction
- 7U22 chain A against the predicted model A5U8D3: TM-score 0.94, RMSD 1.81 Å
- 6VW0 chain A against the predicted model A5U8D3: TM-score 0.94, RMSD 1.67 Å
- 6VW0 chain A against the predicted model A5U8D3: TM-score 0.94, RMSD 1.67 Å
- 6EEC chain A against the predicted model A5U8D3: TM-score 0.94, RMSD 1.71 Å
- 6EEC chain A against the predicted model A5U8D3: TM-score 0.94, RMSD 1.71 Å
- 6VVZ chain A against the predicted model A5U8D3: TM-score 0.94, RMSD 1.80 Å
- 6VVZ chain A against the predicted model A5U8D3: TM-score 0.94, RMSD 1.80 Å
- 7KIN chain A against the predicted model A5U8D3: TM-score 0.94, RMSD 1.87 Å
- 7KIN chain A against the predicted model A5U8D3: TM-score 0.94, RMSD 1.87 Å
- 6EDT chain A against the predicted model A5U8D3: TM-score 0.94, RMSD 1.85 Å
Elsewhere
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