MolNFT v1 · #386598 · protein
AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit alpha (A5U8D3)
A5U8D3: “AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit alpha (A5U8D3)”. 1 pocket (best druggability 0.53). MolNFT v1 #386598 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- A5U8D3
- Type
- protein
- Length
- 347 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x35612D34a32C306CA4fc1edA9360D1F717e25950
- Molecule
- DNA-directed RNA polymerase subunit alpha
- UniProt
- A5U8D3
- Pockets
- 1 · best druggability 0.53
Structure
1 distinct chain · 28% helix, 31% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | DNA-directed RNA polymerase subunit alpha | protein | 347 | 28% helix, 31% strand | A5U8D3 |
Pockets
1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 250 | 0.53 | 0.75 | 24 | empty |
Compared structures
- 8E82 · Mycobacterium tuberculosis RNAP elongation complex with NusG transcription factor · an experimental structure of the same protein · chain A against B, TM-score 0.65
- 8E74 · Mycobacterium tuberculosis RNAP paused elongation complex with NusG transcription factor · an experimental structure of the same protein · chain A against B, TM-score 0.64
- 6EEC · Mycobacterium tuberculosis rnap promoter unwinding intermediate complex with RBPA/CARD… · an experimental structure of the same protein · chain A against B, TM-score 0.64
- 6EEC · Mycobacterium tuberculosis RNAP promoter unwinding intermediate complex with RbpA/CarD… · an experimental structure of the same protein · chain A against B, TM-score 0.64
- 8E8M · Mycobacterium tuberculosis RNAP paused elongation complex · an experimental structure of the same protein · chain A against B, TM-score 0.64
- 6EE8 · Mycobacterium tuberculosis RNAP promoter unwinding intermediate complex with RbpA/CarD… · an experimental structure of the same protein · chain A against B, TM-score 0.64
- 6EE8 · Mycobacterium tuberculosis rnap promoter unwinding intermediate complex with RBPA/CARD… · an experimental structure of the same protein · chain A against B, TM-score 0.64
- 6VVX · Mycobacterium tuberculosis WT RNAP transcription initiation intermediate structure with… · an experimental structure of the same protein · chain A against B, TM-score 0.64
- 6VVX · Mycobacterium tuberculosis wt rnap transcription initiation intermediate structure with… · an experimental structure of the same protein · chain A against B, TM-score 0.64
- 6VVZ · Mycobacterium tuberculosis rnap S456L mutant transcription initiation intermediate… · an experimental structure of the same protein · chain A against B, TM-score 0.64
- 6VVZ · Mycobacterium tuberculosis RNAP S456L mutant transcription initiation intermediate… · an experimental structure of the same protein · chain A against B, TM-score 0.64
- 7KIN · Mycobacterium tuberculosis wt rnap transcription open promoter complex with WHIB7 promoter · an experimental structure of the same protein · chain A against B, TM-score 0.64
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt A5U8D3
- Elsewhere: UniProt A5U8D3 · AlphaFold DB A5U8D3
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