UniProt A0QSL8
DNA-directed RNA polymerase subunit alpha (A0QSL8)
DNA-directed RNA polymerase subunit alpha (UniProt A0QSL8), EC 2.7.7.6: 37 experimental structures and 1 predicted model on GenesisL1, 1 ligand bound, 93 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- A0QSL8
- Protein
- DNA-directed RNA polymerase subunit alpha
- EC
- 2.7.7.6
- Experimental structures
- 37
- Predicted models
- 1
- Ligands
- 1
- Pockets
- 93 · 21 records with a druggable one
Structures
38 records of A0QSL8 in the MolNFT archive: 37 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5TW1 | Crystal structure of a Mycobacterium smegmatis transcription initiation complex with RbpA | x-ray diffraction | A, B, T | — | 4 (best 0.78) |
| 5TW1 | Crystal structure of a mycobacterium smegmatis transcription initiation complex with rbpa | x-ray diffraction | A, B, T | — | — |
| 5VI5 | Structure of Mycobacterium smegmatis transcription initiation complex with a full transcription… | x-ray diffraction | A, B | — | 4 (best 0.73) |
| 5VI5 | Structure of mycobacterium smegmatis transcription initiation complex with a full transcription… | x-ray diffraction | A, B | — | — |
| 5VI8 | Structure of a mycobacterium smegmatis transcription initiation complex with an upstream-fork… | x-ray diffraction | A, B, T | — | 4 (best 0.78) |
| 5VI8 | Structure of a mycobacterium smegmatis transcription initiation complex with an upstream-fork… | x-ray diffraction | A, B, T | — | — |
| 6CCE | Crystal structure of a Mycobacterium smegmatis RNA polymerase transcription initiation complex with… | x-ray diffraction | A, B | SO4 | — |
| 6CCE | Crystal structure of a mycobacterium smegmatis RNA polymerase transcription initiation complex with… | x-ray diffraction | A, B | SO4 | — |
| 6CCV | Crystal structure of a Mycobacterium smegmatis RNA polymerase transcription initiation complex with… | x-ray diffraction | A, B, T | — | 4 (best 0.82) |
| 6CCV | Crystal structure of a mycobacterium smegmatis RNA polymerase transcription initiation complex with… | x-ray diffraction | A, B, T | — | — |
| 6DCF | Crystal structure of a Mycobacterium smegmatis transcription initiation complex with… | x-ray diffraction | A, B | SO4 | 6 (best 0.79) |
| 6DCF | Crystal structure of a mycobacterium smegmatis transcription initiation complex with… | x-ray diffraction | A, B | — | — |
| 6EYD | Structure of Mycobacterium smegmatis RNA polymerase Sigma-A holoenzyme | electron microscopy | A, B | — | 5 (best 0.85) |
| 6EYD | Structure of mycobacterium smegmatis RNA polymerase sigma-a holoenzyme | electron microscopy | A, B | — | — |
| 6F6W | Structure of Mycobacterium smegmatis RNA polymerase core | electron microscopy | A, B | — | 7 (best 0.86) |
| 6F6W | Structure of mycobacterium smegmatis RNA polymerase core | electron microscopy | A, B | — | — |
| 6VVS | Crystal structure of a Mycobacterium smegmatis RNA polymerase transcription initiation complex with… | x-ray diffraction | A, B, T | — | — |
| 6VVS | Crystal structure of a mycobacterium smegmatis RNA polymerase transcription initiation complex with… | x-ray diffraction | A, B, T | — | — |
| 6VVT | Crystal structure of a Mycobacterium smegmatis transcription initiation complex with… | x-ray diffraction | A, B | — | 7 (best 0.81) |
| 6VVT | Crystal structure of a mycobacterium smegmatis transcription initiation complex with… | x-ray diffraction | A, B | — | — |
| 6VVV | Crystal structure of a Mycobacterium smegmatis transcription initiation complex with… | x-ray diffraction | A, B, T | — | 9 (best 0.82) |
| 6VVV | Crystal structure of a mycobacterium smegmatis transcription initiation complex with… | x-ray diffraction | A, B, T | — | — |
| 6YXU | Structure of Mycobacterium smegmatis HelD protein in complex with RNA polymerase core - State I… | electron microscopy | A, B | — | — |
| 6YXU | Structure of mycobacterium smegmatis held protein in complex with RNA polymerase core - state I… | electron microscopy | A, B | — | — |
| 6YYS | Structure of Mycobacterium smegmatis HelD protein in complex with RNA polymerase core - State II… | electron microscopy | A, B | — | 5 (best 0.77) |
| 6YYS | Structure of mycobacterium smegmatis held protein in complex with RNA polymerase core - state II… | electron microscopy | A, B | — | — |
| 6Z11 | Structure of Mycobacterium smegmatis HelD protein in complex with RNA polymerase core - State III… | electron microscopy | A, B | — | 4 (best 0.82) |
| 6Z11 | Structure of mycobacterium smegmatis held protein in complex with RNA polymerase core - state III… | electron microscopy | A, B | — | — |
| 7P5X | Mycobacterial RNAP with transcriptional activator PafBC | electron microscopy | AA, AB | — | 4 (best 0.75) |
| 8Q3I | Mycobacterium smegmatis RNA polymerase in complex with HelD, SigA and RbpA in State I | electron microscopy | A, B | — | 3 (best 0.82) |
| 8QN8 | Mycobacterium smegmatis RNA polymerase in complex with HelD, SigA and RbpA in State II | electron microscopy | A, B | — | 3 (best 0.82) |
| 8QTI | Mycobacterium smegnatis RNAP open promoter complex with SigmaA and RbpA | electron microscopy | A, B | — | 5 (best 0.77) |
| 8QU6 | Mycobacterium smegnatis RNA polymerase transcription initiation complex with SigmaA, RbpA, HelD and… | electron microscopy | A, B | — | 4 (best 0.80) |
| 8R2M | Mycobacterium smegnatis RNA polymerase transcription initiation complex with SigmaA, RbpA, HelD… | electron microscopy | A, B | — | 4 (best 0.78) |
| 8R3M | Mycobacterium smegnatis RNA polymerase transcription initiation complex with SigmaA, RbpA, HelD… | electron microscopy | A, B | — | 4 (best 0.81) |
| 8R6P | Mycobacterium smegnatis RNA polymerase RP2-like transcription initiation complex with SigmaA, RbpA… | electron microscopy | A, B | — | 3 (best 0.81) |
| 8R6R | Mycobacterium smegnatis RNA polymerase RP2-like transcription initiation complex with SigmaA, RbpA… | electron microscopy | A, B | — | 3 (best 0.82) |
| A0QSL8 | AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit alpha (A0QSL8) | predicted | A | — | 1 (best 0.50) |
Ligands
- SO4 · Sulfate ion · in 3 records
Experiment against prediction
- 8QU6 chain A against the predicted model A0QSL8: TM-score 0.96, RMSD 1.53 Å
- 8R3M chain A against the predicted model A0QSL8: TM-score 0.96, RMSD 1.53 Å
- 8QTI chain A against the predicted model A0QSL8: TM-score 0.96, RMSD 1.45 Å
- 7P5X chain AA against the predicted model A0QSL8: TM-score 0.96, RMSD 1.43 Å
- 8R6P chain A against the predicted model A0QSL8: TM-score 0.96, RMSD 1.55 Å
- 8R2M chain A against the predicted model A0QSL8: TM-score 0.96, RMSD 1.53 Å
- 6YYS chain A against the predicted model A0QSL8: TM-score 0.96, RMSD 1.54 Å
- 6YYS chain A against the predicted model A0QSL8: TM-score 0.96, RMSD 1.54 Å
- 6Z11 chain A against the predicted model A0QSL8: TM-score 0.95, RMSD 1.56 Å
- 6Z11 chain A against the predicted model A0QSL8: TM-score 0.95, RMSD 1.56 Å
Elsewhere
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