UniProt A0PQG8
Dihydrofolate reductase (A0PQG8)
Dihydrofolate reductase (UniProt A0PQG8), EC 1.5.1.3: 29 experimental structures on GenesisL1, 23 ligands bound, 19 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- A0PQG8
- Protein
- Dihydrofolate reductase
- EC
- 1.5.1.3
- Experimental structures
- 29
- Predicted models
- 0
- Ligands
- 23
- Pockets
- 19 · 18 records with a druggable one
Structures
29 records of A0PQG8 in the MolNFT archive: 29 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6UWQ | Crystal structure of dihydrofolate reductase from Mycobacterium ulcerans with SDDC-0001565 inhibitor | x-ray diffraction | A | NAP, QKJ | 1 (best 0.72) |
| 6UWQ | Crystal structure of dihydrofolate reductase from mycobacterium ulcerans with sddc-0001565 inhibitor | x-ray diffraction | A | NAP, QKJ | — |
| 6UWW | Crystal structure of dihydrofolate reductase from Mycobacterium ulcerans with P218 inhibitor | x-ray diffraction | A | MMV, SO4, NAP | 1 (best 0.72) |
| 6UWW | Crystal structure of dihydrofolate reductase from mycobacterium ulcerans with P218 inhibitor | x-ray diffraction | A | MMV, SO4, NAP | — |
| 7K68 | Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex… | x-ray diffraction | A | NAP, QKJ, CL | 1 (best 0.73) |
| 7K68 | Crystal structure of dihydrofolate reductase (DHFR) from mycobacterium ulcerans AGY99 in complex… | x-ray diffraction | A | NAP, QKJ, CL | — |
| 7K69 | Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex… | x-ray diffraction | A | NAP, VY7, SER | 1 (best 0.72) |
| 7K69 | Crystal structure of dihydrofolate reductase (DHFR) from mycobacterium ulcerans AGY99 in complex… | x-ray diffraction | A | NAP, VY7 | — |
| 7K6A | Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex… | x-ray diffraction | A | NAP, VYG, CL | 1 (best 0.72) |
| 7K6A | Crystal structure of dihydrofolate reductase (DHFR) from mycobacterium ulcerans AGY99 in complex… | x-ray diffraction | A | NAP, VYG, CL | — |
| 7KI8 | Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex… | x-ray diffraction | A | NAP, WFA | — |
| 7KI8 | Crystal structure of dihydrofolate reductase (DHFR) from mycobacterium ulcerans AGY99 in complex… | x-ray diffraction | A | NAP, WFA | — |
| 7KI9 | Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex… | x-ray diffraction | A | NAP, WFJ | 1 (best 0.72) |
| 7KI9 | Crystal structure of dihydrofolate reductase (DHFR) from mycobacterium ulcerans AGY99 in complex… | x-ray diffraction | A | NAP, WFJ | — |
| 7KM7 | Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex… | x-ray diffraction | A | NAP, WPD, BR | 1 (best 0.72) |
| 7KM7 | Crystal structure of dihydrofolate reductase (DHFR) from mycobacterium ulcerans AGY99 in complex… | x-ray diffraction | A | NAP, WPD, BR | — |
| 7KM8 | Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex… | x-ray diffraction | A, B | NAP, WPD, CL | 1 (best 0.86) |
| 7KM8 | Crystal structure of dihydrofolate reductase (DHFR) from mycobacterium ulcerans AGY99 in complex… | x-ray diffraction | A, B | NAP, WPD, CL | — |
| 7KM9 | Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex… | x-ray diffraction | A | NAP, WPJ, BR, CL | 1 (best 0.73) |
| 7KM9 | Crystal structure of dihydrofolate reductase (DHFR) from mycobacterium ulcerans AGY99 in complex… | x-ray diffraction | A | NAP, WPJ, BR, CL | — |
| 8F80 | Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex… | x-ray diffraction | A | NAP, XJB | 1 (best 0.72) |
| 8F81 | Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex… | x-ray diffraction | A | NAP, XJN | 1 (best 0.73) |
| 8F82 | Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex… | x-ray diffraction | A | XJT, NAP, BR | 1 (best 0.73) |
| 8F83 | Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex… | x-ray diffraction | A | NAP, XJZ | 1 (best 0.73) |
| 8F84 | Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex… | x-ray diffraction | A | NAP, XK8 | 2 (best 0.72) |
| 8F85 | Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex… | x-ray diffraction | A | NAP, XKI | 1 (best 0.74) |
| 8TA0 | Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex… | x-ray diffraction | A | DQI, NAP | 1 (best 0.73) |
| 8TA1 | Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex… | x-ray diffraction | A | NA, EII, NAP | 1 (best 0.74) |
| 8TBR | Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in complex… | x-ray diffraction | A | NAP, HIJ | 1 (best 0.72) |
Ligands
- NAP · Nadp nicotinamide-adenine-dinucleotide phosphate · in 29 records
- CL · Chloride ion · in 8 records
- BR · Bromide ion · in 5 records
- QKJ · 3-(3-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl) oxy]propoxy}phenyl)propanoic acid · in 4 records
- WPD · (2S)-2-[(3-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl) oxy]propoxy}phenyl)methyl]-3,3-difluoropropanoic acid · in 4 records
- MMV · 3-(2-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl) oxy]propoxy}phenyl)propanoic acid · in 2 records
- SO4 · Sulfate ion · in 2 records
- VY7 · 1-{2-[2-(2,4-diamino-5,7-dihydro-6H-pyrrolo[3,4-d]pyrimidin-6-yl)-2-oxoethoxy]phenyl}piperidine-4-carboxylic acid · in 2 records
- VYG · 6-ethyl-5-[3-({3-[4-(trifluoromethyl)piperidin-1-yl]pyridin-2-yl}oxy)propoxy]pyrimidine-2,4-diamine · in 2 records
- WFA · 1-[2-({3-[(2,4-diamino-6-ethylpyrimidin-5-yl) oxy]propyl}amino)phenyl]piperidine-4-carboxylic acid · in 2 records
- WFJ · 1-[2-(3-{[(2,4-diamino-6-ethylpyrimidin-5-yl) oxy]methyl}azetidin-1-yl)phenyl]piperidine-4-carboxylic acid · in 2 records
- WPJ · (2R)-2-[(3-{3-[(2,4-diamino-6-ethylpyrimidin-5-yl) oxy]propoxy}phenyl)methyl]-3,3-difluoropropanoic acid · in 2 records
- DQI · 3-[2-(3-{[(6M)-2,4-diamino-6-(3-methoxyphenyl)pyrimidin-5-yl]oxy}propoxy)phenyl]propanoic acid · in 1 record
- EII · 3-(2-{3-[(2,4-diamino-6-cyclohexylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid · in 1 record
- HIJ · 3-(2-{3-[(2,4-diamino-6-phenylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid · in 1 record
- NA · Sodium ion · in 1 record
- SER · Serine · in 1 record
- XJB · 3-[2-(3-{[2,4-diamino-6-(4-methoxyphenyl)pyrimidin-5-yl]oxy}propoxy)phenyl]propanoic acid · in 1 record
- XJN · 3-(2-{3-[(2,4-diamino-6-pentylpyrimidin-5-yl)oxy]propoxy}phenyl)propanoic acid · in 1 record
- XJT · 3-{2-[3-({(6M)-2,4-diamino-6-[3-(trifluoromethyl)phenyl]pyrimidin-5-yl}oxy)propoxy]phenyl}propanoic acid · in 1 record
- XJZ · 3-{2-[3-({2,4-diamino-6-[4-(trifluoromethyl)phenyl]pyrimidin-5-yl}oxy)propoxy]phenyl}propanoic acid · in 1 record
- XK8 · 3-[2-(3-{[2,4-diamino-6-(4-hydroxybutyl)pyrimidin-5-yl]oxy}propoxy)phenyl]propanoic acid · in 1 record
- XKI · 3-{2-[3-({(6M)-2,4-diamino-6-[2-(trifluoromethyl)phenyl]pyrimidin-5-yl}oxy)propoxy]phenyl}propanoic acid · in 1 record
Elsewhere
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