GL1X · GenesisL1 explorer

Ligand · WFJ

WFJ · 1-[2-(3-{[(2,4-diamino-6-ethylpyrimidin-5-yl) oxy]methyl}azetidin-1-yl)phenyl]piperidine-4-carboxylic acid

WFJ, 1-[2-(3-{[(2,4-diamino-6-ethylpyrimidin-5-yl) oxy]methyl}azetidin-1-yl)phenyl]piperidine-4-carboxylic acid (C22 H30 N6 O3, 426.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every binding site with…

Component
WFJ
Formula
C22 H30 N6 O3
Class
ligand
Structures
2
PDB entries
1

Binding sites

WFJ in 2 structures; the first of them:

  • 7KI9 · Crystal Structure of Dihydrofolate reductase (DHFR) from Mycobacterium ulcerans Agy99 in… · WFJ A202 · binds ILE7, TRP8, ALA9, ILE22, ASP29, LEU30, PHE33, LYS34 and 9 more
  • 7KI9 · Crystal structure of dihydrofolate reductase (DHFR) from mycobacterium ulcerans AGY99 in… · WFJ A202 · binds ILE7, TRP8, ALA9, ILE22, ASP29, LEU30, PHE33, LYS34 and 6 more

Residues it binds most

ILE 2, LEU 2, ALA 2, ARG 2, ASP 2, HIS 2, LYS 2, PHE 2, PRO 1, THR 2 (residue and the binding sites it lines).

Found with

  • NAP · Nadp nicotinamide-adenine-dinucleotide phosphate

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