UniProt A0A0S4TER9
Bifunctional dihydrofolate reductase-thymidylate synthase (A0A0S4TER9)
Bifunctional dihydrofolate reductase-thymidylate synthase (UniProt A0A0S4TER9): 28 experimental structures on GenesisL1, 17 ligands bound, 235 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- A0A0S4TER9
- Protein
- Bifunctional dihydrofolate reductase-thymidylate synthase
- Experimental structures
- 28
- Predicted models
- 0
- Ligands
- 17
- Pockets
- 235 · 12 records with a druggable one
Structures
28 records of A0A0S4TER9 in the MolNFT archive: 28 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 6OJS | Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP, MTX and… | x-ray diffraction | A, B, C, D, E | NDP, UFP, D96, MTX | 20 (best 0.79) |
| 6OJS | Crystal structure of ts-DHFR from cryptosporidium hominis in complex with NADPH, fdump, mtx and… | x-ray diffraction | A, B, C, D, E | NDP, UFP, D96 | — |
| 6PF7 | Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and… | x-ray diffraction | A, B, C, D, E | NDP, UFP, OG7, MTX, SO4 | 20 (best 0.79) |
| 6PF7 | Crystal structure of ts-DHFR from cryptosporidium hominis in complex with NADPH, fdump and… | x-ray diffraction | A, B, C, D, E | NDP, UFP, OG7, SO4 | — |
| 6PF8 | Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and… | x-ray diffraction | A, B, C, D, E | NDP, UFP, OE7, MTX | 20 (best 0.80) |
| 6PF8 | Crystal structure of ts-DHFR from cryptosporidium hominis in complex with NADPH, fdump and… | x-ray diffraction | A, B, C, D, E | NDP, UFP, OE7 | — |
| 6PF9 | Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and… | x-ray diffraction | A, B, C, D, E | NDP, UFP, OF7, SO4 | — |
| 6PF9 | Crystal structure of ts-DHFR from cryptosporidium hominis in complex with NADPH, fdump and… | x-ray diffraction | A, B, C, D, E | NDP, UFP, OF7, SO4 | — |
| 6PFA | Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and… | x-ray diffraction | A, B, C, D, E | NDP, UFP, OF4, MTX, SO4 | 20 (best 0.79) |
| 6PFA | Crystal structure of ts-DHFR from cryptosporidium hominis in complex with NADPH, fdump and… | x-ray diffraction | A, B, C, D, E | NDP, UFP, OF4, SO4 | — |
| 6PFB | Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and… | x-ray diffraction | A, B, C, D, E | NDP, UFP, OG4, MTX | 20 (best 0.78) |
| 6PFB | Crystal structure of ts-DHFR from cryptosporidium hominis in complex with NADPH, fdump and… | x-ray diffraction | A, B, C, D, E | NDP, UFP, OG4 | — |
| 6PFC | Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and… | x-ray diffraction | A, B, C, D, E | NDP, UFP, OED, MTX | 20 (best 0.79) |
| 6PFC | Crystal structure of ts-DHFR from cryptosporidium hominis in complex with NADPH, fdump and… | x-ray diffraction | A, B, C, D, E | NDP, UFP, OED | — |
| 6PFD | Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and… | x-ray diffraction | A, B, C, D, E | NDP, UFP, OEJ, MTX | 20 (best 0.81) |
| 6PFD | Crystal structure of ts-DHFR from cryptosporidium hominis in complex with NADPH, fdump and… | x-ray diffraction | A, B, C, D, E | NDP, UFP, OEJ | — |
| 6PFE | Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and… | x-ray diffraction | A, B, C, D, E | NDP, UFP, OEA | — |
| 6PFE | Crystal structure of ts-DHFR from cryptosporidium hominis in complex with NADPH, fdump and… | x-ray diffraction | A, B, C, D, E | NDP, UFP, OEA | — |
| 6PFF | Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and… | x-ray diffraction | A, B, C, D, E | NDP, UFP, OG1, MTX, SO4 | 20 (best 0.79) |
| 6PFF | Crystal structure of ts-DHFR from cryptosporidium hominis in complex with NADPH, fdump and… | x-ray diffraction | A, B, C, D, E | NDP, UFP, OG1, SO4 | — |
| 6PFG | Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and… | x-ray diffraction | A, B, C, D, E | NDP, UFP, OFJ, MTX, SO4 | 20 (best 0.79) |
| 6PFG | Crystal structure of ts-DHFR from cryptosporidium hominis in complex with NADPH, fdump and… | x-ray diffraction | A, B, C, D, E | NDP, UFP, OFJ, SO4 | — |
| 6PFH | Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and… | x-ray diffraction | A, B, C, D, E | NDP, UFP, OFD, MTX | 20 (best 0.80) |
| 6PFH | Crystal structure of ts-DHFR from cryptosporidium hominis in complex with NADPH, fdump and… | x-ray diffraction | A, B, C, D, E | NDP, UFP, OFD | — |
| 6PFI | Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and… | x-ray diffraction | A, B, C, D, E | NDP, UFP, OEP, MTX | 20 (best 0.79) |
| 6PFI | Crystal structure of ts-DHFR from cryptosporidium hominis in complex with NADPH, fdump and… | x-ray diffraction | A, B, C, D, E | NDP, UFP, OEP | — |
| 6WEP | Crystal structure of TS-DHFR from Cryptosporidium hominis with Apo-TS site | x-ray diffraction | A, B | NDP, MTX | 15 (best 0.74) |
| 6WEP | Crystal structure of ts-DHFR from cryptosporidium hominis with apo-ts site | x-ray diffraction | A, B | NDP | — |
Ligands
- NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · in 28 records
- UFP · 5-fluoro-2'-deoxyuridine-5'-monophosphate · in 26 records
- MTX · Methotrexate · in 12 records
- SO4 · Sulfate ion · in 10 records
- D96 · N-{4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}-D-glutamic acid · in 2 records
- OE7 · 2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)-4-chlorobenzoic acid · in 2 records
- OEA · 2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)-4-methoxybenzoic acid · in 2 records
- OED · [2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)-4-methoxyphenyl]acetic acid · in 2 records
- OEJ · 2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino) benzene-1,4-dicarboxylic acid · in 2 records
- OEP · 3-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)-4-(carboxymethyl)benzoic acid · in 2 records
- OF4 · 2-[({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino) methyl]benzoic acid · in 2 records
- OF7 · [2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino) phenyl]acetic acid · in 2 records
- OFD · [2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)-4-cyanophenyl]acetic acid · in 2 records
- OFJ · 2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)-4-carbamoylbenzoic acid · in 2 records
- OG1 · 2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)-4-cyanobenzoic acid · in 2 records
- OG4 · 3-[2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino) phenyl]propanoic acid · in 2 records
- OG7 · 2-({4-[(2-amino-4-oxo-4,7-dihydro-1H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino) benzoic acid · in 2 records
Elsewhere
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