MolNFT v1 · #160265 · protein

Crystal structure of ts-DHFR from cryptosporidium hominis in complex with NADPH, fdump and 2-(4-((2-amino-4-oxo-4,7-dihydro-3H-PYRROLO[2, 3-D]PYRIMIDIN-5-YL)METHYL)BENZAMIDO)-4-methoxybenzoic acid.

6PFE: “Crystal structure of ts-DHFR from cryptosporidium hominis in complex with NADPH, fdump and…”. X-ray diffraction, 3 ligands (NDP, UFP, OEA). MolNFT v1 #160265 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6PFE
Type: protein
Length: 2,538 residues
Chains: 5
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: A0A0S4TER9
Ligands: NDP, UFP, OEA

Structure

x-ray diffraction · 3 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, B	—	protein	507	—	A0A0S4TER9
C, D	—	protein	509	—	A0A0S4TER9
E	—	protein	506	—	A0A0S4TER9

Ligands and binding sites

NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · ligand · 5 copies · chains A, B, C, D, E
UFP · 5-fluoro-2'-deoxyuridine-5'-monophosphate · ligand · 5 copies · chains A, B, C, E, D
OEA · 2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino)-4-methoxybenzoic acid · ligand · 5 copies · chains A, B, C, D, E

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6PFE · Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP… · the same entry in another collection · chain C against C, TM-score 1.00

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt A0A0S4TER9
Elsewhere: RCSB PDB 6PFE · PDBe 6PFE · UniProt A0A0S4TER9

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