Crystal structure of TS-DHFR from Cryptosporidium hominis in complex with NADPH, FdUMP and 2-(2-(4-((2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl)benzamido)phenyl)acetic acid.

Structure

x-ray diffraction · resolution 2.89 · 2 distinct chains.

Ligands and binding sites

• NDP · Nadph dihydro-nicotinamide-adenine-dinucleotide phosphate · ligand · 5 copies · chains A, B, C, D, E
• UFP · 5-fluoro-2'-deoxyuridine-5'-monophosphate · ligand · 5 copies · chains A, B, C, D, E
• OF7 · [2-({4-[(2-amino-4-oxo-4,7-dihydro-3H-pyrrolo[2,3-d]pyrimidin-5-yl)methyl]benzene-1-carbonyl}amino) phenyl]acetic acid · ligand · 5 copies · chains A, B, C, D, E
• SO4 · Sulfate ion · ion · 5 copies · chains A, B, C, D, E

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

• 6PF9 · Crystal structure of ts-DHFR from cryptosporidium hominis in complex with NADPH, fdump… · the same entry in another collection · chain A against A, TM-score 1.00

Analyse

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• Every structure of UniProt A0A0S4TER9
• Elsewhere: RCSB PDB 6PF9 · PDBe 6PF9 · UniProt A0A0S4TER9