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Ligand · RYK

RYK · (5~{R})-5-[(1~{S})-4,5-dimethoxy-1,3-dihydro-2-benzofuran-1-yl]-~{N}-ethyl-4-methoxy-7,8-dihydro-5~{H}-[1,3]dioxolo[4,5-g]isoquinoline-6-carboxamide

RYK, (5~{R})-5-[(1~{S})-4,5-dimethoxy-1,3-dihydro-2-benzofuran-1-yl]-~{N}-ethyl-4-methoxy-7,8-dihydro-5~{H}-[1,3]dioxolo[4,5-g]isoquinoline-6-carboxamide (C24 H28 N2 O7, 456.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2…

Component
RYK
Formula
C24 H28 N2 O7
Class
ligand
Structures
2
PDB entries
1

Binding sites

RYK in 2 structures; the first of them:

  • 7AU5 · Tubulin-noscapine-analogue-14e complex · RYK B507 · binds THR179, ALA180, VAL181, TYR202, VAL238, CYS241, LEU242, GLY246 and 16 more
  • 7AU5 · Tubulin-noscapine-analogue-14E complex · RYK B507 · binds THR179, ALA180, VAL181, TYR202, VAL238, CYS241, LEU242, GLY246 and 16 more

Residues it binds most

ALA 2, THR 2, VAL 2, ASN 2, ILE 2, LEU 2, LYS 2, ASP 2, CYS 2, GLY 2 (residue and the binding sites it lines).

Found with

  • ACP · Phosphomethylphosphonic acid adenylate ester
  • GDP · Guanosine-5'-diphosphate
  • GTP · Guanosine-5'-triphosphate
  • CA · Calcium ion
  • MG · Magnesium ion
  • GOL · Glycerol
  • IMD · Imidazole
  • MES · 2-(N-morpholino)-ethanesulfonic acid

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