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Ligand · RTZ

RTZ · 10-{2-[(2R)-1-methylpiperidin-2-yl]ethyl}-2-(methylsulfanyl)-10H-phenothiazine

RTZ, 10-{2-[(2R)-1-methylpiperidin-2-yl]ethyl}-2-(methylsulfanyl)-10H-phenothiazine (C21 H26 N2 S2, 370.6 g/mol), in the MolNFT structures on GenesisL1: bound in 3 records (2 PDB entries). Every binding site with its residues within 4.5 Å…

Component
RTZ
Formula
C21 H26 N2 S2
Class
ligand
Structures
3
PDB entries
2

Binding sites

RTZ in 3 structures; the first of them:

  • 6CSB · V308E mutant of cytochrome P450 2D6 complexed with thioridazine · RTZ A602 · binds LEU110, PHE112, PHE120, LEU121, ALA209, GLY212, LEU213, GLU216 and 3 more
  • 6CSB · V308E mutant of cytochrome P450 2D6 complexed with thioridazine · RTZ A602 · binds LEU110, PHE112, PHE120, LEU121, ALA209, GLY212, LEU213, GLU216 and 3 more
  • 6G95 · Crystal structure of ebolavirus glycoprotein in complex with thioridazine · RTZ B708 · binds GLY36, VAL37, ILE38, LEU43, LEU184, ILE185, LEU186, LEU515 and 4 more

Residues it binds most

LEU 17, PHE 12, GLY 17, ALA 10, THR 8, GLU 14, VAL 7, ASP 8, GLN 8, SER 8 (residue and the binding sites it lines).

Found with

  • GOL · Glycerol
  • 2CV · Hega-10
  • HEM · Protoporphyrin IX containing Fe
  • ZN · Zinc ion
  • ACT · Acetate ion
  • BMA · beta-D-mannopyranose
  • MAN · alpha-D-mannopyranose
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • DMS · Dimethyl sulfoxide

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