GL1X · GenesisL1 explorer

Ligand · LZU

LZU · 10-{2-[(2S)-1-methylpiperidin-2-yl]ethyl}-2-(methylsulfanyl)-10H-phenothiazine

LZU, 10-{2-[(2S)-1-methylpiperidin-2-yl]ethyl}-2-(methylsulfanyl)-10H-phenothiazine (C21 H26 N2 S2, 370.6 g/mol), in the MolNFT structures on GenesisL1: bound in 4 records (2 PDB entries). Every binding site with its residues within 4.5 Å…

Component
LZU
Formula
C21 H26 N2 S2
Class
ligand
Structures
4
PDB entries
2

Binding sites

LZU in 4 structures; the first of them:

  • 4I1R · Human MALT1 (caspase-IG3) in complex with thioridazine · LZU A801 · binds VAL344, ALA345, LEU346, LYS379, VAL381, ASN393, ALA394, GLU397 and 8 more
  • 4UHX · Human aldehyde oxidase in complex with phthalazine and thioridazine · LZU A3008 · binds HIS575, GLU577, ASP578, SER1060, ARG1061, ARG1064, MET1065, PRO1066 and 3 more
  • 4I1R · Human MALT1 (caspase-IG3) in complex with thioridazine · LZU A801 · binds VAL344, ALA345, LEU346, LYS379, VAL381, ASN393, ALA394, GLU397 and 8 more
  • 4UHX · Human aldehyde oxidase in complex with phthalazine and thioridazine · LZU A3008 · binds HIS575, GLU577, ASP578, SER1060, ARG1061, ARG1064, MET1065, PRO1066 and 3 more

Residues it binds most

LEU 2, ARG 4, TRP 4, ALA 2, GLU 4, MET 4, VAL 2, ASN 2, ASP 2, GLN 2 (residue and the binding sites it lines).

Found with

  • 4FT · phthalazine
  • FAD · Flavin-adenine dinucleotide
  • FES · Fe2/s2 (inorganic) cluster
  • MOS · Dioxothiomolybdenum(vi) ion
  • MTE · Phosphonic acidmono-(2-amino-5,6-dimercapto-4-oxo-3,7,8A,9,10,10A-hexahydro-4H-8-oxa-1,3,9,10-tetraaza-anthracen-7-ylmethyl)ester
  • RTZ · 10-{2-[(2R)-1-methylpiperidin-2-yl]ethyl}-2-(methylsulfanyl)-10H-phenothiazine
  • MLI · Malonate ion

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