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Ligand · HF2

HF2 · (2R)-2-hydroxy-3-phenylpropanoic acid

HF2, (2R)-2-hydroxy-3-phenylpropanoic acid (C9 H10 O3, 166.2 g/mol), in the MolNFT structures on GenesisL1: bound in 19 records (10 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands…

Component
HF2
Formula
C9 H10 O3
Class
ligand
Structures
19
PDB entries
10

Binding sites

HF2 in 19 structures; the first of them:

  • 4KIB · Crystal structure of methyltransferase from Streptomyces hygroscopicus complexed with… · HF2 A404 · binds ASP309, PHE312, CYS319, VAL320, LYS321, LYS322, PHE334
  • 4KIC · Crystal structure of methyltransferase from Streptomyces hygroscopicus complexed with… · HF2 A404 · binds ASP309, PHE312, CYS319, VAL320, LYS321, LYS322, PHE334
  • 4KIF · Crystal structure of methyltransferase from Streptomyces hygroscopicus complexed with… · HF2 A503 · binds ASP309, PHE312, CYS319, VAL320, LYS321, LYS322, PHE334
  • 4M6X · Mutant structure of methyltransferase from Streptomyces hygroscopicus complexed with… · HF2 A404 · binds ASP309, PHE312, CYS319, VAL320, LYS321, LYS322, PHE334
  • 4M6Y · Mutant structure of methyltransferase from Streptomyces hygroscopicus complexed with… · HF2 A404 · binds ASP309, PHE312, CYS319, VAL320, LYS321, LYS322, PHE334
  • 4M71 · Mutant structure of methyltransferase from Streptomyces hygroscopicus complexed with… · HF2 A404 · binds ASP309, PHE312, CYS319, VAL320, LYS321, LYS322, PHE334
  • 4M72 · Mutant structure of methyltransferase from Streptomyces hygroscopicus · HF2 A404 · binds ASP309, PHE312, CYS319, VAL320, LYS321, LYS322, PHE334
  • 4M73 · Mutant structure of methyltransferase from Streptomyces hygroscopicus · HF2 A404 · binds ASP309, PHE312, CYS319, VAL320, LYS321, LYS322, PHE334
  • 4M74 · Mutant structure of methyltransferase from Streptomyces hygroscopicus · HF2 A404 · binds ASP309, PHE312, CYS319, VAL320, LYS321, LYS322, PHE334
  • 3AH8 · Structure of heterotrimeric G protein galpha-Q beta gamma in complex with an inhibitor… · HF2 Y6 · binds SER53, ILE56, LYS57, ARG60, TYR67, PHE75, VAL184, ILE190 and 5 more
  • 4KIB · Crystal structure of methyltransferase from streptomyces hygroscopicus complexed with… · HF2 A404 · binds ASP309, PHE312, CYS319, VAL320, LYS321, LYS322, PHE334
  • 4KIC · Crystal structure of methyltransferase from streptomyces hygroscopicus complexed with… · HF2 A404 · binds ASP309, PHE312, CYS319, VAL320, LYS321, LYS322, PHE334
  • 4KIF · Crystal structure of methyltransferase from streptomyces hygroscopicus complexed with… · HF2 A503 · binds ASP309, PHE312, CYS319, VAL320, LYS321, LYS322, PHE334
  • 4M6X · Mutant structure of methyltransferase from streptomyces hygroscopicus complexed with… · HF2 A404 · binds ASP309, PHE312, CYS319, VAL320, LYS321, LYS322, PHE334
  • 4M6Y · Mutant structure of methyltransferase from streptomyces hygroscopicus complexed with… · HF2 A404 · binds ASP309, PHE312, CYS319, VAL320, LYS321, LYS322, PHE334
  • 4M71 · Mutant structure of methyltransferase from streptomyces hygroscopicus complexed with… · HF2 A404 · binds ASP309, PHE312, CYS319, VAL320, LYS321, LYS322, PHE334
  • 4M72 · Mutant structure of methyltransferase from streptomyces hygroscopicus · HF2 A404 · binds ASP309, PHE312, CYS319, VAL320, LYS321, LYS322, PHE334
  • 4M73 · Mutant structure of methyltransferase from streptomyces hygroscopicus · HF2 A404 · binds ASP309, PHE312, CYS319, VAL320, LYS321, LYS322, PHE334
  • 4M74 · Mutant structure of methyltransferase from streptomyces hygroscopicus · HF2 A404 · binds ASP309, PHE312, CYS319, VAL320, LYS321, LYS322, PHE334

Residues it binds most

LYS 37, PHE 37, VAL 37, ASP 36, CYS 36, ILE 1, ALA 1, ARG 1, DAM 1, HL2 1 (residue and the binding sites it lines).

Found with

  • CA · Calcium ion
  • FE · Fe (III) ion
  • SAH · S-adenosyl-L-homocysteine
  • 56D · (3R)-2-oxo-3-phenylbutanoic acid
  • IOD · Iodide ion
  • M72 · (2R,3R)-2-hydroxy-3-methoxy-3-phenylpropanoic acid
  • PPY · 3-phenylpyruvic acid
  • M74 · (2S,3R)-2,3-dihydroxy-3-phenylpropanoic acid
  • SAM · S-adenosylmethionine
  • OXY · Oxygen molecule
  • ACE · Acetyl group
  • GDP · Guanosine-5'-diphosphate

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