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Ligand · GU1

GU1 · 2,3-di-O-methyl-beta-D-glucopyranuronic acid

GU1, 2,3-di-O-methyl-beta-D-glucopyranuronic acid (C8 H14 O7, 222.2 g/mol), in the MolNFT structures on GenesisL1: bound in 12 records (6 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the…

Component
GU1
Formula
C8 H14 O7
Class
sugar
Structures
12
PDB entries
6

Binding sites

GU1 in 12 structures; the first of them:

  • 1AZX · ANTITHROMBIN/PENTASACCHARIDE complex · GU1 A4 · binds LYS11, THR44, ASN45, ARG46, LYS125
  • 1E03 · Plasma alpha antithrombin-III and pentasaccharide · GU1 E4 · binds LYS11, ASN45
  • 1NQ9 · Crystal Structure of Antithrombin in the Pentasaccharide-Bound Intermediate State · GU1 D4 · binds THR44, ASN45, ARG46
  • 1TB6 · 2.5A Crystal Structure of the Antithrombin-Thrombin-Heparin Ternary Complex · GU1 B4 · binds LYS11, THR44, ASN45, ARG46, LYS125
  • 2B5T · 2.1 Angstrom structure of a nonproductive complex between antithrombin, synthetic heparin… · GU1 G4 · binds LYS11, ASN45
  • 3KCG · Crystal structure of the antithrombin-factor IXa-pentasaccharide complex · GU1 D4 · binds THR44, ASN45, LYS125
  • 1AZX · ANTITHROMBIN/PENTASACCHARIDE complex · GU1 A4 · binds LYS11, THR44, ASN45, ARG46, LYS125
  • 1E03 · Plasma alpha antithrombin-III and pentasaccharide · GU1 E4 · binds LYS11, ASN45
  • 1NQ9 · Crystal structure of antithrombin in the pentasaccharide-bound intermediate state · GU1 D4 · binds THR44, ASN45, ARG46
  • 1TB6 · 2.5A crystal structure of the antithrombin-thrombin-heparin ternary complex · GU1 B4 · binds LYS11, THR44, ASN45, ARG46, LYS125
  • 2B5T · 2.1 ångström structure of a nonproductive complex between antithrombin, synthetic heparin… · GU1 G4 · binds LYS11, ASN45
  • 3KCG · Crystal structure of the antithrombin-factor ixa-pentasaccharide complex · GU1 D4 · binds THR44, ASN45, LYS125

Residues it binds most

LYS 16, ASN 18, THR 12, ARG 10 (residue and the binding sites it lines).

Found with

  • GU6 · 2,3,6-tri-O-sulfo-alpha-D-glucopyranose
  • NAG · 2-acetamido-2-deoxy-beta-D-glucopyranose
  • Z9K · 3-O-methyl-2-O-sulfo-alpha-L-idopyranuronic acid
  • Z9L · methyl 2,3,6-tri-O-sulfo-alpha-D-glucopyranoside
  • Z9H · 3,4-di-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranose
  • BMA · beta-D-mannopyranose
  • FUC · alpha-L-fucopyranose
  • MAN · alpha-D-mannopyranose
  • GU4 · 2,3,4,6-tetra-O-sulfonato-alpha-D-glucopyranose
  • GU0 · 2,3,6-tri-O-sulfonato-beta-D-glucopyranose
  • GU2 · 2,3-di-O-methyl-alpha-L-idopyranuronic acid
  • GU3 · methyl 3-O-methyl-2,6-di-O-sulfo-alpha-D-glucopyranoside

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