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Ligand · DON

DON · 6-diazenyl-5-oxo-L-norleucine

DON, 6-diazenyl-5-oxo-L-norleucine (C6 H11 N3 O3, 173.2 g/mol), in the MolNFT structures on GenesisL1: bound in 5 records (5 PDB entries). Every binding site with its residues within 4.5 Å, the residues it binds most and the ligands found…

Component
DON
Formula
C6 H11 N3 O3
Class
ligand
Structures
5
PDB entries
5

Binding sites

DON in 5 structures; the first of them:

  • 5Y9B · Crystal structure of Bacillus licheniformis Gamma glutamyl transpeptidase with DON · DON B603 · binds ARG109, THR399, THR417, GLU419, GLU438, ASP441, SER460, SER461 and 5 more
  • 7D9W · Gamma-glutamyltranspeptidase from Pseudomonas nitroreducens complexed with L-DON · DON B601 · binds ARG94, THR364, THR382, ASN384, GLU403, ASP406, PHE417, SER435 and 6 more
  • 7DPT · Structural basis for ligand binding modes of CTP synthase · DON A702 · binds GLY371, GLY372, PHE373, ILE398, CYS399, LEU400, GLN403, GLU423 and 6 more
  • 9IZ1 · dmCTPS tetramer with dATP dUTP dGTP and DON · DON A601 · binds GLY371, GLY372, PHE373, ILE398, CYS399, LEU400, GLN403, GLU423 and 5 more
  • 9IZ2 · Focus refinement dmCTPS bound with dATP dUTP dGTP and DON · DON A601 · binds GLY371, GLY372, PHE373, ILE398, CYS399, LEU400, GLN403, GLU423 and 5 more

Residues it binds most

GLY 12, ARG 12, HIS 9, GLN 9, GLU 12, ILE 12, PHE 11, CYS 9, LEU 9, TYR 9 (residue and the binding sites it lines).

Found with

  • 5ZL · [[(2~{R},3~{S},4~{R},5~{R})-3,4-bis(oxidanyl)-5-(2-oxidanyl-4-phosphonooxy-pyrimidin-1-yl)oxolan-2-yl]methoxy-oxidanyl-phosphoryl] phosphono hydrogen phosphate
  • MG · Magnesium ion
  • DAT · 2'-deoxyadenosine-5'-diphosphate
  • DGT · 2'-deoxyguanosine-5'-triphosphate
  • ADP · Adenosine-5'-diphosphate
  • GLY · Glycine
  • GTP · Guanosine-5'-triphosphate
  • CA · Calcium ion
  • EDO · 1,2-ethanediol

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