MolNFT v2 · #210787 · protein
CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#11 of 20)
8GEA: “CryoEM structure of beta-2-adrenergic receptor in complex with nucleotide-free Gs heterotrimer (#11 of 20)”. Electron microscopy at 3.5, 1 ligand (G1I). MolNFT v2 #210787 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 8GEA
- Type
- protein
- Length
- 902 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.5
- Source
- Homo sapiens
- UniProt
- P63092, P62873, P59768, P07550
- Ligands
- G1I
Structure
electron microscopy · resolution 3.5 · 4 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 240 | — | P63092 |
| B | — | protein | 330 | — | P62873 |
| G | — | protein | 50 | — | P59768 |
| R | — | protein | 282 | — | P07550 |
Ligands and binding sites
- G1I · (5R,6R)-6-(methylamino)-5,6,7,8-tetrahydronaphthalene-1,2,5-triol · ligand · chains R
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 1.00
- P07550 · AlphaFold monomer V2.0 prediction for beta-2 adrenergic receptor (P07550) · a predicted model of the same protein · chain R against A, TM-score 0.95
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain G against A, TM-score 0.89
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63092
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Every structure of UniProt P07550
- Elsewhere: RCSB PDB 8GEA · PDBe 8GEA · UniProt P63092 · UniProt P62873 · UniProt P59768 · UniProt P07550
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