MolNFT v2 · #202784 · protein
CryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(open) complex
7ZR6: “CryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(open) complex”. Electron microscopy at 4.2, 1 ligand (ATP). MolNFT v2 #202784 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7ZR6
- Type
- protein
- Length
- 2,168 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 4.2
- Source
- Homo sapiens
- UniProt
- P08238, Q16543, P15056, P53041
- Ligands
- ATP
Structure
electron microscopy · resolution 4.2 · 5 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 633 | — | P08238 |
| B | — | protein | 631 | — | P08238 |
| C | — | protein | 277 | — | Q16543 |
| K | — | protein | 186 | — | P15056 |
| P | — | protein | 441 | — | P53041 |
Ligands and binding sites
- ATP · Adenosine-5'-triphosphate · ligand · 2 copies · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- P08238 · AlphaFold monomer V2.0 prediction for heat shock protein HSP 90-beta (P08238) · a predicted model of the same protein · chain A against A, TM-score 0.92
- P15056 · AlphaFold monomer V2.0 prediction for SERINE/THREONINE-protein kinase B-RAF (P15056) · a predicted model of the same protein · chain K against A, TM-score 0.78
- Q16543 · AlphaFold monomer V2.0 prediction for HSP90 co-chaperone CDC37 (Q16543) · a predicted model of the same protein · chain C against A, TM-score 0.45
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P08238
- Every structure of UniProt Q16543
- Every structure of UniProt P15056
- Every structure of UniProt P53041
- Elsewhere: RCSB PDB 7ZR6 · PDBe 7ZR6 · UniProt P08238 · UniProt Q16543 · UniProt P15056 · UniProt P53041
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