UniProt Q16543
Hsp90 co-chaperone Cdc37 (Q16543)
Hsp90 co-chaperone Cdc37 (UniProt Q16543): 21 experimental structures and 1 predicted model on GenesisL1, 26 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- Q16543
- Protein
- Hsp90 co-chaperone Cdc37
- Experimental structures
- 21
- Predicted models
- 1
- Pockets
- 26 · 4 records with a druggable one
Structures
22 records of Q16543 in the MolNFT archive: 21 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1US7 | Complex of Hsp90 and P50 | x-ray diffraction | B | — | — |
| 1US7 | Complex of HSP90 and P50 | x-ray diffraction | B | — | — |
| 2K5B | Human CDC37-HSP90 docking model based on NMR | solution nmr | B | — | — |
| 2K5B | Human CDC37-HSP90 docking model based on NMR | solution nmr | B | — | — |
| 2N5X | C-terminal domain of Cdc37 cochaperone | solution nmr | A | — | — |
| 2N5X | C-terminal domain of CDC37 cochaperone | solution nmr | A | — | — |
| 2NCA | Structural Model for the N-terminal Domain of Human Cdc37 | solution nmr | A | — | — |
| 2NCA | Structural model for the N-terminal domain of human CDC37 | solution nmr | A | — | — |
| 2W0G | HSP90 co-chaperone CDC37 | x-ray diffraction | A | — | — |
| 2W0G | HSP90 co-chaperone CDC37 | x-ray diffraction | A | — | — |
| 5FWK | Atomic cryoEM structure of Hsp90-Cdc37-Cdk4 complex | electron microscopy | E | — | — |
| 5FWK | Atomic cryoem structure of HSP90-CDC37-CDK4 complex | electron microscopy | E | — | — |
| 5FWL | Atomic cryoEM structure of Hsp90-Cdc37-Cdk4 complex | electron microscopy | E | — | — |
| 5FWL | Atomic cryoem structure of HSP90-CDC37-CDK4 complex | electron microscopy | E | — | — |
| 5FWM | Atomic cryoEM structure of Hsp90-Cdc37-Cdk4 complex | electron microscopy | E | — | 9 (best 0.83) |
| 5FWM | Atomic cryoem structure of HSP90-CDC37-CDK4 complex | electron microscopy | E | — | — |
| 5FWP | Atomic cryoEM structure of Hsp90-Cdc37-Cdk4 complex | electron microscopy | E | — | 5 (best 0.83) |
| 5FWP | Atomic cryoem structure of HSP90-CDC37-CDK4 complex | electron microscopy | E | — | — |
| 7Z37 | Structure of the RAF1-HSP90-CDC37 complex (RHC-II) | electron microscopy | DP1 | — | 7 (best 0.84) |
| 7ZR6 | CryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(open) complex | electron microscopy | C | — | — |
| 8U1L | Cryo-EM structure of the RAF1-HSP90-CDC37 complex in the closed state | electron microscopy | D | — | 5 (best 0.87) |
| Q16543 | AlphaFold monomer V2.0 prediction for HSP90 co-chaperone CDC37 (Q16543) | predicted | A | — | — |
Experiment against prediction
- 2W0G chain A against the predicted model Q16543: TM-score 0.97, RMSD 0.82 Å
- 2W0G chain A against the predicted model Q16543: TM-score 0.97, RMSD 0.82 Å
- 2K5B chain B against the predicted model Q16543: TM-score 0.97, RMSD 0.87 Å
- 2K5B chain B against the predicted model Q16543: TM-score 0.97, RMSD 0.87 Å
- 1US7 chain B against the predicted model Q16543: TM-score 0.91, RMSD 1.77 Å
- 1US7 chain B against the predicted model Q16543: TM-score 0.91, RMSD 1.77 Å
- 5FWK chain E against the predicted model Q16543: TM-score 0.81, RMSD 2.13 Å
- 5FWK chain E against the predicted model Q16543: TM-score 0.81, RMSD 2.13 Å
- 8U1L chain D against the predicted model Q16543: TM-score 0.68, RMSD 2.34 Å
- 2N5X chain A against the predicted model Q16543: TM-score 0.57, RMSD 1.98 Å
Elsewhere
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