MolNFT v1 · #24341 · protein
Complex of HSP90 and P50
1US7 · Heat shock protein HSP82: “Complex of HSP90 and P50”. X-ray diffraction, 2 pockets (best druggability 0.70). MolNFT v1 #24341 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1US7
- Type
- protein
- Length
- 399 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Heat shock protein HSP82; HSP90 co-chaperone CDC37
- UniProt
- P02829, Q16543
- Pockets
- 2 · best druggability 0.70
Structure
x-ray diffraction · 2 distinct chains · 60% helix, 12% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Heat shock protein HSP82 | protein | 206 | 47% helix, 23% strand | P02829 |
| B | HSP90 co-chaperone CDC37 | protein | 193 | 74% helix, 0% strand | Q16543 |
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 650 | 0.70 | 0.78 | 55 | empty |
| 2 | 72 | 0.43 | 0.80 | 10 | empty |
Interfaces
1 interface between chains.
- A–B · 593 Ų buried · 8 hydrogen bonds · protein-protein
Compared structures
- 1US7 · Complex of Hsp90 and P50 · the same entry in another collection · chain A against A, TM-score 1.00
- Q16543 · AlphaFold monomer V2.0 prediction for HSP90 co-chaperone CDC37 (Q16543) · a predicted model of the same protein · chain B against A, TM-score 0.91
- P02829 · AlphaFold monomer V2.0 prediction for ATP-dependent molecular chaperone HSP82 (P02829) · a predicted model of the same protein · chain A against A, TM-score 0.82
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P02829
- Every structure of UniProt Q16543
- Elsewhere: RCSB PDB 1US7 · PDBe 1US7 · UniProt P02829 · UniProt Q16543
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