UniProt P08238
Heat shock protein HSP 90-beta (P08238)
Heat shock protein HSP 90-beta (UniProt P08238): 42 experimental structures and 1 predicted model on GenesisL1, 16 ligands bound, 440 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P08238
- Protein
- Heat shock protein HSP 90-beta
- Experimental structures
- 42
- Predicted models
- 1
- Ligands
- 16
- Pockets
- 440 · 40 records with a druggable one
Structures
43 records of P08238 in the MolNFT archive: 42 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1QZ2 | Crystal Structure of FKBP52 C-terminal Domain complex with the C-terminal peptide MEEVD of Hsp90 | x-ray diffraction | G, H | — | 2 (best 0.60) |
| 1QZ2 | Crystal structure of FKBP52 C-terminal domain complex with the C-terminal peptide meevd of HSP90 | x-ray diffraction | G, H | — | 2 (best 0.60) |
| 1UYM | Human Hsp90-beta with PU3 (9-Butyl-8(3,4,5-trimethoxy-benzyl)-9H-purin-6-ylamine) | x-ray diffraction | A | PU3 | 1 (best 0.69) |
| 1UYM | Human HSP90-beta with PU3 (9-butyl-8(3,4,5-trimethoxy-benzyl)-9H- purin-6-ylamine) | x-ray diffraction | A | PU3 | 1 (best 0.69) |
| 3FWV | Crystal Structure of a Redesigned TPR Protein, T-MOD(VMY), in Complex with MEEVF Peptide | x-ray diffraction | C, D | — | 2 (best 0.48) |
| 3FWV | Crystal structure of a redesigned tpr protein, T-MOD(VMY), in complex with meevf peptide | x-ray diffraction | C, D | ACE | 2 (best 0.48) |
| 3NMQ | Hsp90b N-terminal domain in complex with EC44, a pyrrolo-pyrimidine methoxypyridine inhibitor | x-ray diffraction | A | 7PP | 1 (best 0.68) |
| 3NMQ | HSP90B N-terminal domain in complex with EC44, a pyrrolo-pyrimidine methoxypyridine inhibitor | x-ray diffraction | A | 7PP | 1 (best 0.68) |
| 3PRY | Crystal structure of the middle domain of human HSP90-beta refined at 2.3 A resolution | x-ray diffraction | A, B, C | SO4 | 6 (best 0.76) |
| 3PRY | Crystal structure of the middle domain of human HSP90-beta refined at 2.3 a resolution | x-ray diffraction | A, B, C | SO4 | 6 (best 0.76) |
| 5FWK | Atomic cryoEM structure of Hsp90-Cdc37-Cdk4 complex | electron microscopy | A, B | ATP, MG | 20 (best 0.86) |
| 5FWK | Atomic cryoem structure of HSP90-CDC37-CDK4 complex | electron microscopy | A, B | ATP, MG | 20 (best 0.86) |
| 5FWL | Atomic cryoEM structure of Hsp90-Cdc37-Cdk4 complex | electron microscopy | A, B | ATP, MG | 20 (best 0.83) |
| 5FWL | Atomic cryoem structure of HSP90-CDC37-CDK4 complex | electron microscopy | A, B | ATP, MG | 20 (best 0.83) |
| 5FWM | Atomic cryoEM structure of Hsp90-Cdc37-Cdk4 complex | electron microscopy | A, B | ATP, MG | 18 (best 0.83) |
| 5FWM | Atomic cryoem structure of HSP90-CDC37-CDK4 complex | electron microscopy | A, B | ATP, MG | 18 (best 0.83) |
| 5FWP | Atomic cryoEM structure of Hsp90-Cdc37-Cdk4 complex | electron microscopy | A, B | ATP, MG | 20 (best 0.83) |
| 5FWP | Atomic cryoem structure of HSP90-CDC37-CDK4 complex | electron microscopy | A, B | ATP, MG | 20 (best 0.83) |
| 5UC4 | Hsp90b N-terminal domain with inhibitors | x-ray diffraction | A, B, C, D | 83S | 6 (best 0.74) |
| 5UC4 | HSP90B N-terminal domain with inhibitors | x-ray diffraction | A, B, C, D | 83S | 6 (best 0.74) |
| 5UCH | Hsp90b N-terminal domain with inhibitors | x-ray diffraction | A, B, C, D | 871 | 8 (best 0.74) |
| 5UCH | HSP90B N-terminal domain with inhibitors | x-ray diffraction | A, B, C, D | 871 | 8 (best 0.74) |
| 5UCI | Hsp90b N-terminal domain with inhibitors | x-ray diffraction | A, B, C, D | 874 | 6 (best 0.69) |
| 5UCI | HSP90B N-terminal domain with inhibitors | x-ray diffraction | A, B, C, D | 874 | 6 (best 0.69) |
| 5UCJ | Hsp90b N-terminal domain with inhibitors | x-ray diffraction | A, B, C, D | KU3 | 6 (best 0.82) |
| 5UCJ | HSP90B N-terminal domain with inhibitors | x-ray diffraction | A, B, C, D | KU3 | 6 (best 0.82) |
| 6N8W | Structure of Unliganded Hsp90-Beta N-Terminal Domain | x-ray diffraction | A, B, C, D | — | 8 (best 0.64) |
| 6N8W | Structure of unliganded HSP90-beta N-terminal domain | x-ray diffraction | A, B, C, D | — | 8 (best 0.64) |
| 6N8Y | Hsp90-beta bound to PU-11-trans | x-ray diffraction | A | KFY | 1 (best 0.71) |
| 6N8Y | HSP90-beta bound to pu-11-trans | x-ray diffraction | A | KFY | 1 (best 0.71) |
| 7ULJ | Hsp90b N-terminal domain in complex with 42C | x-ray diffraction | A, B, C, D | 42C | 6 (best 0.81) |
| 7Z37 | Structure of the RAF1-HSP90-CDC37 complex (RHC-II) | electron microscopy | AP1, BP1 | ATP | 17 (best 0.84) |
| 7Z38 | Structure of the RAF1-HSP90-CDC37 complex (RHC-I) | electron microscopy | A, B | ATP, MG | 20 (best 0.84) |
| 7ZR0 | CryoEM structure of HSP90-CDC37-BRAF(V600E) complex. | electron microscopy | A, B | ATP | 17 (best 0.85) |
| 7ZR5 | CryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(closed) complex | electron microscopy | A, B | ATP | 18 (best 0.84) |
| 7ZR6 | CryoEM structure of HSP90-CDC37-BRAF(V600E)-PP5(open) complex | electron microscopy | A, B | ATP | 12 (best 0.87) |
| 7ZUB | Cryo-EM structure of the indirubin-bound Hsp90-XAP2-AHR complex | electron microscopy | A, B | ADP, MG, MOO | 17 (best 0.82) |
| 8EOA | Cryo-EM structure of human HSP90B-AIPL1 complex | electron microscopy | A, B | ANP, MG | 17 (best 0.81) |
| 8EOB | Cryo-EM structure of human HSP90B in the closed state | electron microscopy | A, B | ANP, MG | 17 (best 0.81) |
| 8GAE | Hsp90 provides platform for CRaf dephosphorylation by PP5 | electron microscopy | A, B | K, MG, ADP, ATP | 16 (best 0.87) |
| 8GFT | Hsp90 provides platform for CRaf dephosphorylation by PP5 | electron microscopy | A, B | ADP, MG, K, ATP | 15 (best 0.84) |
| 8QMO | Cryo-EM structure of the benzo[a]pyrene-bound Hsp90-XAP2-AHR complex | electron microscopy | A, B | MOO, ADP, MG | 18 (best 0.83) |
| P08238 | AlphaFold monomer V2.0 prediction for heat shock protein HSP 90-beta (P08238) | predicted | A | — | — |
Ligands
- ATP · Adenosine-5'-triphosphate · in 15 records
- MG · Magnesium ion · in 15 records
- ADP · Adenosine-5'-diphosphate · in 4 records
- 7PP · 5-{2-amino-4-chloro-7-[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]-7H-pyrrolo[2,3-d]pyrimidin-5-yl}-2-methylpent-4-yn-2 -ol · in 2 records
- 83S · 5-Hydroxy-4-(isoindoline-2-carbonyl)-2-isopropylbenzaldehyde · in 2 records
- 871 · 2-(5-Hydroxy-4-(isoindoline-2-carbonyl)-2-isopropylphenyl)acetonitrile · in 2 records
- 874 · (2,4-dihydroxy-3-(hydroxymethyl)-5-isopropylphenyl) (isoindolin-2-yl)methanone · in 2 records
- ANP · Phosphoaminophosphonic acid-adenylate ester · in 2 records
- K · Potassium ion · in 2 records
- KFY · 9-[(2E)-but-2-en-1-yl]-8-[(3,4,5-trimethoxyphenyl) methyl]-9H-purin-6-amine · in 2 records
- KU3 · (5-fluoroisoindolin-2-yl)(4-hydroxy-5-isopropylbenzo[d]isoxazol-7-yl)methanone · in 2 records
- MOO · Molybdate ion · in 2 records
- PU3 · 9-butyl-8-(3,4,5-trimethoxybenzyl)-9H-purin-6-amine · in 2 records
- SO4 · Sulfate ion · in 2 records
- 42C · N,N-dimethyl-7H-purin-6-amine · in 1 record
- ACE · Acetyl group · in 1 record
Experiment against prediction
- 8EOB chain A against the predicted model P08238: TM-score 0.97, RMSD 1.53 Å
- 8EOB chain B against the predicted model P08238: TM-score 0.97, RMSD 1.55 Å
- 8EOA chain B against the predicted model P08238: TM-score 0.97, RMSD 1.61 Å
- 8EOA chain A against the predicted model P08238: TM-score 0.97, RMSD 1.63 Å
- 7Z38 chain B against the predicted model P08238: TM-score 0.96, RMSD 1.80 Å
- 7Z38 chain A against the predicted model P08238: TM-score 0.96, RMSD 1.79 Å
- 7Z37 chain BP1 against the predicted model P08238: TM-score 0.96, RMSD 1.82 Å
- 7Z37 chain AP1 against the predicted model P08238: TM-score 0.96, RMSD 1.80 Å
- 8GAE chain B against the predicted model P08238: TM-score 0.96, RMSD 1.90 Å
- 8GFT chain B against the predicted model P08238: TM-score 0.96, RMSD 1.94 Å
Elsewhere
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