MolNFT v1 · #135875 · protein

HSP90B N-terminal domain with inhibitors

5UC4: “HSP90B N-terminal domain with inhibitors”. X-ray diffraction, 1 ligand (83S). MolNFT v1 #135875 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 5UC4
Type: protein
Length: 855 residues
Chains: 4
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
UniProt: P08238
Ligands: 83S

Structure

x-ray diffraction · 3 distinct chains.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	219	—	P08238
B, D	—	protein	209	—	P08238
C	—	protein	218	—	P08238

Ligands and binding sites

83S · 5-Hydroxy-4-(isoindoline-2-carbonyl)-2-isopropylbenzaldehyde · ligand · 4 copies · chains A, B, C, D
DMS · Dimethyl sulfoxide · additive · 4 copies · chains A, B, C, D
GOL · Glycerol · additive · 2 copies · chains A, B, C

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

5UC4 · Hsp90b N-terminal domain with inhibitors · the same entry in another collection · chain A against A, TM-score 1.00
P08238 · AlphaFold monomer V2.0 prediction for heat shock protein HSP 90-beta (P08238) · a predicted model of the same protein · chain B against A, TM-score 0.81

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P08238
Elsewhere: RCSB PDB 5UC4 · PDBe 5UC4 · UniProt P08238

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