MolNFT v2 · #195640 · protein
Cryo-EM structure of the relaxin receptor RXFP1 in complex with heterotrimeric Gs
7TMW · Relaxin receptor 1, Guanine nucleotide-binding protein G(s)…: “Cryo-EM structure of the relaxin receptor RXFP1 in complex with heterotrimeric Gs”. Electron microscopy at 3.2, 7 pockets (best druggability 0.83). MolNFT v2 #195640 on…
- PDB
- 7TMW
- Type
- protein
- Length
- 930 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.2
- Source
- Homo sapiens; Lama glama
- Molecule
- Relaxin receptor 1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short…
- UniProt
- Q9HBX9, P63092, P62873, P59768
- Pockets
- 7 · best druggability 0.83
Structure
electron microscopy · resolution 3.2 · 4 distinct chains · 36% helix, 25% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| R | Relaxin receptor 1, Guanine nucleotide-binding protein G(s) subunit alpha isoforms short fusion | protein | 499 | 67% helix, 7% strand | Q9HBX9, P63092 |
| B | Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1 | protein | 298 | 0% helix, 49% strand | P62873 |
| C | Guanine nucleotide-binding protein G(I)/G(S)/G(O) subunit gamma-2 | protein | 7 | 0% helix, 0% strand | P59768 |
| N | Camelid antibody VHH fragment Nb35 | protein | 126 | 3% helix, 42% strand | — |
Pockets
7 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 657 | 0.83 | 0.88 | 53 | empty |
| 2 | 1117 | 0.76 | 0.79 | 83 | empty |
| 3 | 106 | 0.64 | 0.89 | 23 | empty |
| 4 | 140 | 0.63 | 0.86 | 31 | empty |
| 5 | 123 | 0.50 | 0.80 | 24 | empty |
Interfaces
4 interfaces between chains.
- R–B · 1702 Ų buried · 17 hydrogen bonds · protein-protein
- R–N · 882 Ų buried · 10 hydrogen bonds · protein-protein
- B–N · 518 Ų buried · 5 hydrogen bonds · protein-protein
- B–C · 353 Ų buried · 0 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 4 disulfide (disulfide).
Compared structures
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain C against A, TM-score 0.64
- Q9HBX9 · AlphaFold monomer V2.0 prediction for relaxin receptor 1 (Q9HBX9) · a predicted model of the same protein · chain R against A, TM-score 0.54
- P63092 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(S) subunit… · a predicted model of the same protein · chain R against A, TM-score 0.41
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9HBX9
- Every structure of UniProt P63092
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Elsewhere: RCSB PDB 7TMW · PDBe 7TMW · UniProt Q9HBX9 · UniProt P63092 · UniProt P62873 · UniProt P59768
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