MolNFT v2 · #189250 · protein
Crystal structure of the human METTL3-METTL14 complex with compound UOZ038
7OEF: “Crystal structure of the human METTL3-METTL14 complex with compound UOZ038”. X-ray diffraction at 2.03, 1 ligand (VAT). MolNFT v2 #189250 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7OEF
- Type
- protein
- Length
- 439 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.03
- Source
- Homo sapiens
- UniProt
- Q86U44, Q9HCE5
- Ligands
- VAT
Structure
x-ray diffraction · resolution 2.03 · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 198 | — | Q86U44 |
| B | — | protein | 241 | — | Q9HCE5 |
Ligands and binding sites
- VAT · 4-(2-azaspiro[3.4]octan-2-ylmethyl)-~{N}-[[(3~{R})-3-oxidanyl-1-[6-[(phenylmethyl)amino]pyrimidin-4-yl]piperidin-3-yl]methyl]benzamide · ligand · chains A
- ACT · Acetate ion · additive · chains A, B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7OEF · Crystal structure of the human METTL3-METTL14 complex with compound UOZ038 · the same entry in another collection · chain A against A, TM-score 1.00
- Q9HCE5 · AlphaFold monomer V2.0 prediction for N6-adenosine-methyltransferase non-catalytic… · a predicted model of the same protein · chain B against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q86U44
- Every structure of UniProt Q9HCE5
- Elsewhere: RCSB PDB 7OEF · PDBe 7OEF · UniProt Q86U44 · UniProt Q9HCE5
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