MolNFT v2 · #185250 · protein
cryo-EM structure of DkTx-bound minimal TRPV1 at the pre-bound state
7L2S: “cryo-EM structure of DkTx-bound minimal TRPV1 at the pre-bound state”. Electron microscopy at 2.71, 3 ligands (XJ7, 6IY, NA). MolNFT v2 #185250 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7L2S
- Type
- protein
- Length
- 2,506 residues
- Chains
- 4
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.71
- Source
- Rattus norvegicus
- UniProt
- O35433
- Ligands
- XJ7, 6IY, NA
Structure
electron microscopy · resolution 2.71 · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| D, A, B | — | protein | 626 | — | O35433 |
| C | — | protein | 628 | — | O35433 |
Ligands and binding sites
- XJ7 · (2S)-1-(butanoyloxy)-3-{[(R)-hydroxy{[(1r,2r,3s,4s,5r, 6S)-2,3,4,5,6-pentahydroxycyclohexyl]oxy}phosphoryl]oxy}propan-2-yl tridecanoate · ligand · 4 copies · chains D, A, B, C
- 6IY · (10R,13S)-16-amino-13-hydroxy-7,13-dioxo-8,12,14-trioxa-13lambda~5~-phosphahexadecan-10-yl hexadecanoate · ligand · 4 copies · chains D, A, B, C
- NA · Sodium ion · metal · chains D, A, B, C
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7L2S · Cryo-EM structure of dktx-bound minimal TRPV1 at the pre-bound state · the same entry in another collection · chain A against A, TM-score 1.00
- O35433 · AlphaFold monomer V2.0 prediction for transient receptor potential cation channel… · a predicted model of the same protein · chain C against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O35433
- Elsewhere: RCSB PDB 7L2S · PDBe 7L2S · UniProt O35433
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