MolNFT v2 · #180049 · protein
Cryo-EM structure of ozanimod -bound Sphingosine-1-phosphate receptor 1 in complex with Gi protein
7EW0: “Cryo-EM structure of ozanimod -bound Sphingosine-1-phosphate receptor 1 in complex with Gi protein”. Electron microscopy at 3.42, 1 ligand (JEU). MolNFT v2 #180049 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 7EW0
- Type
- protein
- Length
- 1,142 residues
- Chains
- 5
- Method
- electron microscopy
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 3.42
- Source
- Homo sapiens; Mus musculus
- UniProt
- P63096, P62873, P59768
- Ligands
- JEU
Structure
electron microscopy · resolution 3.42 · 5 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 228 | — | P63096 |
| B | — | protein | 340 | — | P62873 |
| C | — | protein | 58 | — | P59768 |
| D | — | protein | 284 | — | — |
| E | — | protein | 232 | — | — |
Ligands and binding sites
- JEU · 5-[3-[(1~{S})-1-(2-hydroxyethylamino)-2,3-dihydro-1~{H}-inden-4-yl]-1,2,4-oxadiazol-5-yl]-2-propan-2-yloxy-benzenecarbonitrile · ligand · chains D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7EW0 · Cryo-EM structure of ozanimod -bound sphingosine-1-phosphate receptor 1 in complex with… · the same entry in another collection · chain E against E, TM-score 1.00
- P62873 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
- P59768 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(O)… · a predicted model of the same protein · chain C against A, TM-score 0.85
- P63096 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.80
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P63096
- Every structure of UniProt P62873
- Every structure of UniProt P59768
- Elsewhere: RCSB PDB 7EW0 · PDBe 7EW0 · UniProt P63096 · UniProt P62873 · UniProt P59768
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