MolNFT v2 · #179572 · protein + DNA + RNA
Thermus thermophilus RNA polymerase transcription initiation complex containing a template-strand purine at position TSS-2, UpA RNA primer and CMPcPP
7EH0: “Thermus thermophilus RNA polymerase transcription initiation complex containing a template-strand purine at…”. X-ray diffraction at 2.808, 3 ligands (2TM, MG, ZN). MolNFT v2 #179572 on GenesisL1: 3D structure, binding sites and…
- PDB
- 7EH0
- Type
- protein + DNA + RNA
- Length
- 3,537 residues
- Chains
- 9
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 2.808
- Source
- Thermus thermophilus HB8; SYNTHETIC CONSTRUCT
- UniProt
- Q5SHR6, Q8RQE9, Q8RQE8, Q8RQE7, Q5SKW1
- Ligands
- 2TM, MG, ZN
Structure
x-ray diffraction · resolution 2.808 · 9 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | — | protein | 231 | — | Q5SHR6 |
| B | — | protein | 224 | — | Q5SHR6 |
| C | — | protein | 1112 | — | Q8RQE9 |
| D | — | protein | 1486 | — | Q8RQE8 |
| E | — | protein | 94 | — | Q8RQE7 |
| F | — | protein | 346 | — | Q5SKW1 |
| G | — | dna | 25 | — | — |
| H | — | dna | 17 | — | — |
| I | — | rna | 2 | — | — |
Ligands and binding sites
- 2TM · 5'-O-[(S)-hydroxy{[(s)-hydroxy(phosphonooxy) phosphoryl]methyl}phosphoryl]cytidine · ligand · chains C, D, H, I
- MG · Magnesium ion · metal · 5 copies · chains B, D, I, F
- ZN · Zinc ion · metal · 2 copies · chains D
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 7EH0 · Thermus thermophilus RNA polymerase transcription initiation complex containing a… · the same entry in another collection · chain H against H, TM-score 1.00
- Q8RQE9 · AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit beta (Q8RQE9) · a predicted model of the same protein · chain C against A, TM-score 0.98
- Q8RQE8 · AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit beta' (Q8RQE8) · a predicted model of the same protein · chain D against A, TM-score 0.98
- Q8RQE7 · AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit omega (Q8RQE7) · a predicted model of the same protein · chain E against A, TM-score 0.98
- Q5SHR6 · AlphaFold monomer V2.0 prediction for DNA-directed RNA polymerase subunit alpha (Q5SHR6) · a predicted model of the same protein · chain A against A, TM-score 0.95
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q5SHR6
- Every structure of UniProt Q8RQE9
- Every structure of UniProt Q8RQE8
- Every structure of UniProt Q8RQE7
- Every structure of UniProt Q5SKW1
- Elsewhere: RCSB PDB 7EH0 · PDBe 7EH0 · UniProt Q5SHR6 · UniProt Q8RQE9 · UniProt Q8RQE8 · UniProt Q8RQE7 · UniProt Q5SKW1
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