MolNFT v2 · #173525 · protein

SYK Kinase domain in complex with diamine inhibitor 16

6ZCY: “SYK Kinase domain in complex with diamine inhibitor 16”. X-ray diffraction at 1.81, 1 ligand (QF8). MolNFT v2 #173525 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 6ZCY
Type: protein
Length: 265 residues
Chains: 1
Method: x-ray diffraction
Collection: MolNFT v2 / PDB Bank
Contract: 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
Owner: 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
Resolution: 1.81
Source: Homo sapiens
UniProt: P43405
Ligands: QF8

Structure

x-ray diffraction · resolution 1.81 · 1 distinct chain.

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	—	protein	265	—	P43405

Ligands and binding sites

QF8 · ~{N},1-dimethyl-5-[[4-[3-methyl-4-[[(3~{R})-pyrrolidin-3-yl]amino]pyrazol-1-yl]pyrimidin-2-yl]amino]indazole-3-carboxamide · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Compared structures

6ZCY · Syk kinase domain in complex with diamine inhibitor 16 · the same entry in another collection · chain A against A, TM-score 1.00
P43405 · AlphaFold monomer V2.0 prediction for tyrosine-protein kinase syk (P43405) · a predicted model of the same protein · chain A against A, TM-score 0.91

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P43405
Elsewhere: RCSB PDB 6ZCY · PDBe 6ZCY · UniProt P43405

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