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Ligand · QF8

QF8 · ~{N},1-dimethyl-5-[[4-[3-methyl-4-[[(3~{R})-pyrrolidin-3-yl]amino]pyrazol-1-yl]pyrimidin-2-yl]amino]indazole-3-carboxamide

QF8, ~{N},1-dimethyl-5-[[4-[3-methyl-4-[[(3~{R})-pyrrolidin-3-yl]amino]pyrazol-1-yl]pyrimidin-2-yl]amino]indazole-3-carboxamide (C22 H26 N10 O, 446.5 g/mol), in the MolNFT structures on GenesisL1: bound in 2 records (1 PDB entry). Every…

Component
QF8
Formula
C22 H26 N10 O
Class
ligand
Structures
2
PDB entries
1

Binding sites

QF8 in 2 structures; the first of them:

  • 6ZCY · SYK Kinase domain in complex with diamine inhibitor 16 · QF8 A701 · binds LEU377, GLY378, VAL385, ALA400, MET448, GLU449, MET450, ALA451 and 7 more
  • 6ZCY · Syk kinase domain in complex with diamine inhibitor 16 · QF8 A701 · binds LEU377, GLY378, VAL385, ALA400, MET448, GLU449, MET450, ALA451 and 7 more

Residues it binds most

ALA 2, GLU 2, GLY 2, LEU 2, MET 2, ARG 2, ASN 2, ASP 2, PRO 2, VAL 2 (residue and the binding sites it lines).

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