MolNFT v2 · #137494 · protein
A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole and CyPPA
5V02: “A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole and CyPPA”. X-ray diffraction at 1.78, 3 ligands (657, CA, SO4). MolNFT v2 #137494 on GenesisL1: 3D structure, binding sites and pockets in…
- PDB
- 5V02
- Type
- protein
- Length
- 233 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v2 / PDB Bank
- Contract
- 0xd58B01f6C18086e5202cdC5D7Ad3E41790360102
- Owner
- 0xF4e1AA6f26B7DA48EeAD9B24a97927303eeA07b8
- Resolution
- 1.78
- Source
- Homo sapiens
- UniProt
- Q9H2S1, P0DP23
- Ligands
- 657, CA, SO4
Structure
x-ray diffraction · resolution 1.78 · 2 distinct chains.
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | — | protein | 87 | — | Q9H2S1 |
| R | — | protein | 146 | — | P0DP23 |
Ligands and binding sites
- 657 · 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine · ligand · chains B, R
- CA · Calcium ion · metal · 2 copies · chains R
- SO4 · Sulfate ion · ion · 2 copies · chains B
- GOL · Glycerol · additive · chains R
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Compared structures
- 5V02 · A positive allosteric modulator binding pocket in SK2 ion channels is shared by riluzole… · the same entry in another collection · chain B against B, TM-score 1.00
- Q9H2S1 · AlphaFold monomer V2.0 prediction for small conductance calcium- activated potassium… · a predicted model of the same protein · chain B against A, TM-score 0.70
- P0DP23 · AlphaFold monomer V2.0 prediction for calmodulin-1 (P0DP23) · a predicted model of the same protein · chain R against A, TM-score 0.51
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q9H2S1
- Every structure of UniProt P0DP23
- Elsewhere: RCSB PDB 5V02 · PDBe 5V02 · UniProt Q9H2S1 · UniProt P0DP23
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