UniProt Q9H2S1
Small conductance calcium-activated potassium channel protein 2 (Q9H2S1)
Small conductance calcium-activated potassium channel protein 2 (UniProt Q9H2S1): 8 experimental structures and 1 predicted model on GenesisL1, 6 ligands bound, 5 pockets. Binding sites, druggability and experiment against…
- UniProt
- Q9H2S1
- Protein
- Small conductance calcium-activated potassium channel protein 2
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 6
- Pockets
- 5 · 2 records with a druggable one
Structures
9 records of Q9H2S1 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 5V02 | A positive allosteric modulator binding pocket in SK2 ion channels is shared by Riluzole and CyPPA | x-ray diffraction | B | SO4, 657 | — |
| 5V02 | A positive allosteric modulator binding pocket in SK2 ion channels is shared by riluzole and cyppa | x-ray diffraction | B | SO4, 657 | — |
| 5V03 | A positive allosteric modulator binding pocket in SK2 ion channels is shared by riluzole and cyppa | x-ray diffraction | B | SO4, 658 | — |
| 5WBX | Structural insights into the potency of SK/IK channel positive modulators | x-ray diffraction | B | SO4, AJY | — |
| 5WBX | Structural insights into the potency of SK/IK channel positive modulators | x-ray diffraction | B | SO4, AJY | — |
| 5WC5 | Structural insights into the potency of SK/IK channel positive modulators | x-ray diffraction | B | SO4, AJV | 1 (best 0.69) |
| 5WC5 | Structural insights into the potency of SK/IK channel positive modulators | x-ray diffraction | B | SO4, AJV | — |
| 6ALE | A V-to-F substitution in SK2 channels causes CA2+ hypersensitivity and improves locomotion in a C.… | x-ray diffraction | B | SO4, 1KP | — |
| Q9H2S1 | AlphaFold monomer V2.0 prediction for small conductance calcium- activated potassium channel… | predicted | A | — | 4 (best 0.58) |
Ligands
- SO4 · Sulfate ion · in 8 records
- 657 · 6-(trifluoromethoxy)-1,3-benzothiazol-2-amine · in 2 records
- AJV · 7-fluoro-3-(hydroxyamino)-2H-indol-2-one · in 2 records
- AJY · (3Z)-6-bromo-3-(hydroxyimino)-5-methyl-1,3-dihydro-2H-indol-2-one · in 2 records
- 1KP · (3E)-6,7-dichloro-3-(hydroxyimino)-1,3-dihydro-2H-indol-2-one · in 1 record
- 658 · N-(4-chlorophenyl)-2-(3,5-dimethyl-1H-pyrazol-1-yl) pyrimidin-4-amine · in 1 record
Experiment against prediction
- 5V03 chain B against the predicted model Q9H2S1: TM-score 0.71, RMSD 2.25 Å
- 5V02 chain B against the predicted model Q9H2S1: TM-score 0.70, RMSD 2.31 Å
- 5V02 chain B against the predicted model Q9H2S1: TM-score 0.70, RMSD 2.31 Å
- 6ALE chain B against the predicted model Q9H2S1: TM-score 0.66, RMSD 2.74 Å
- 5WC5 chain B against the predicted model Q9H2S1: TM-score 0.66, RMSD 2.76 Å
- 5WC5 chain B against the predicted model Q9H2S1: TM-score 0.66, RMSD 2.76 Å
- 5WBX chain B against the predicted model Q9H2S1: TM-score 0.65, RMSD 2.79 Å
- 5WBX chain B against the predicted model Q9H2S1: TM-score 0.65, RMSD 2.79 Å
Elsewhere
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