Crystal structure of SUFUD60-GLI1P

Structure

x-ray diffraction · 2 distinct chains · 28% helix, 28% strand (DSSP).

Ligands and binding sites

• GOL · Glycerol · additive · 6 copies · chains A
• DTT · 2,3-dihydroxy-1,4-dithiobutane · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Interfaces

1 interface between chains.

• A–B · 759 Ų buried · 19 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 1 covalent (additive adduct).

Compared structures

• 4KMD · Crystal structure of Sufud60-Gli1p · the same entry in another collection · chain A against A, TM-score 1.00
• Q9UMX1 · AlphaFold monomer V2.0 prediction for suppressor of fused homolog (Q9UMX1) · a predicted model of the same protein · chain A against A, TM-score 0.75
• P08151 · AlphaFold monomer V2.0 prediction for zinc finger protein GLI1 (P08151) · a predicted model of the same protein · chain B against A, TM-score 0.34

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt Q9UMX1
• Every structure of UniProt P08151
• Elsewhere: RCSB PDB 4KMD · PDBe 4KMD · UniProt Q9UMX1 · UniProt P08151