UniProt P08151
Isoform 2 of Zinc finger protein GLI1 (P08151)
Isoform 2 of Zinc finger protein GLI1 (UniProt P08151): 8 experimental structures and 1 predicted model on GenesisL1, 3 ligands bound, 3 pockets. Binding sites, druggability and experiment against prediction (TM-score) in GL1X.
- UniProt
- P08151
- Protein
- Isoform 2 of Zinc finger protein GLI1
- Experimental structures
- 8
- Predicted models
- 1
- Ligands
- 3
- Pockets
- 3 · 1 record with a druggable one
Structures
9 records of P08151 in the MolNFT archive: 8 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 2GLI | Five-finger GLI/DNA complex | x-ray diffraction | A | CO | 2 (best 0.80) |
| 2GLI | Five-finger GLI/DNA complex | x-ray diffraction | A | — | — |
| 4BLB | Crystal structure of a human Suppressor of fused (SUFU)-GLI1p complex | x-ray diffraction | E, F, G, H | — | — |
| 4BLB | Crystal structure of a human suppressor of fused (sufu)-GLI1P complex | x-ray diffraction | E, F, G, H | — | — |
| 4KMD | Crystal structure of Sufud60-Gli1p | x-ray diffraction | B | — | — |
| 4KMD | Crystal structure of SUFUD60-GLI1P | x-ray diffraction | B | — | — |
| 5OM0 | CH2 chimera of human 14-3-3 sigma with the GLI1 phosphopeptide around SER640 | x-ray diffraction | A, B | SO4 | — |
| 7T91 | Crystal structure of Zinc finger motif 1 and 2 of GLI1 DNA binding region | x-ray diffraction | A, B | ZN | 1 (best 0.43) |
| P08151 | AlphaFold monomer V2.0 prediction for zinc finger protein GLI1 (P08151) | predicted | A | — | — |
Ligands
Experiment against prediction
- 5OM0 chain A against the predicted model P31947: TM-score 0.97, RMSD 1.31 Å
- 5OM0 chain B against the predicted model P31947: TM-score 0.94, RMSD 1.00 Å
- 2GLI chain A against the predicted model P08151: TM-score 0.92, RMSD 1.51 Å
- 2GLI chain A against the predicted model P08151: TM-score 0.92, RMSD 1.51 Å
- 7T91 chain A against the predicted model P08151: TM-score 0.50, RMSD 3.34 Å
- 7T91 chain B against the predicted model P08151: TM-score 0.48, RMSD 2.92 Å
- 4BLB chain G against the predicted model P08151: TM-score 0.40, RMSD 1.77 Å
- 4BLB chain G against the predicted model P08151: TM-score 0.40, RMSD 1.77 Å
- 4KMD chain B against the predicted model P08151: TM-score 0.34, RMSD 1.10 Å
- 4KMD chain B against the predicted model P08151: TM-score 0.34, RMSD 1.10 Å
Elsewhere
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