MolNFT v1 · #9433 · protein
1:2 complex of human growth hormone with its soluble binding protein
1HWG: “1:2 complex of human growth hormone with its soluble binding protein”. X-ray diffraction, 5 pockets (best druggability 0.68). MolNFT v1 #9433 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1HWG
- Type
- protein
- Length
- 569 residues
- Chains
- 3
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Growth hormone; Growth hormone binding protein
- UniProt
- P01241, P10912
- Pockets
- 5 · best druggability 0.68
Structure
x-ray diffraction · 3 distinct chains · 24% helix, 33% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Growth hormone | protein | 184 | 67% helix, 0% strand | P01241 |
| B | Growth hormone binding protein | protein | 194 | 4% helix, 49% strand | P10912 |
| C | Growth hormone binding protein | protein | 191 | 4% helix, 48% strand | P10912 |
Pockets
5 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 784 | 0.68 | 0.75 | 69 | empty |
| 2 | 124 | 0.48 | 0.79 | 22 | empty |
| 3 | 131 | 0.44 | 0.77 | 27 | empty |
| 4 | 77 | 0.37 | 0.77 | 15 | empty |
| 5 | 71 | 0.34 | 0.75 | 13 | empty |
Interfaces
3 interfaces between chains.
- A–B · 1344 Ų buried · 15 hydrogen bonds · protein-protein
- A–C · 878 Ų buried · 9 hydrogen bonds · protein-protein
- B–C · 485 Ų buried · 9 hydrogen bonds · protein-protein
Modifications
Observed in the structure: 8 disulfide (disulfide).
Compared structures
- 1HWG · 1:2 complex of human growth hormone with its soluble binding protein · the same entry in another collection · chain A against A, TM-score 1.00
- P10912 · AlphaFold monomer V2.0 prediction for growth hormone receptor (P10912) · a predicted model of the same protein · chain B against A, TM-score 0.98
- P01241 · AlphaFold monomer V2.0 prediction for somatotropin (P01241) · a predicted model of the same protein · chain A against A, TM-score 0.87
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01241
- Every structure of UniProt P10912
- Elsewhere: RCSB PDB 1HWG · PDBe 1HWG · UniProt P01241 · UniProt P10912
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