MolNFT v1 · #93711 · protein

Crystal structure of px domain of human sorting nexin SNX27

4HAS · Sorting nexin-27: “Crystal structure of px domain of human sorting nexin SNX27”. X-ray diffraction, 2 pockets (best druggability 0.41). MolNFT v1 #93711 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4HAS
Type: protein
Length: 207 residues
Chains: 2
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Sorting nexin-27
UniProt: Q96L92
Pockets: 2 · best druggability 0.41

Structure

x-ray diffraction · 2 distinct chains · 41% helix, 26% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Sorting nexin-27	protein	104	40% helix, 26% strand	Q96L92
B	Sorting nexin-27	protein	103	42% helix, 26% strand	Q96L92

Ligands and binding sites

CIT · Citric acid · additive · chains A
EDO · 1,2-ethanediol · additive · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

2 pockets found on a 1 Å grid, 0 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	153	0.41	0.74	23	empty
2	80	0.30	0.73	16	empty

Interfaces

1 interface between chains.

A–B · 308 Å² buried · 7 hydrogen bonds · protein-protein

Compared structures

4HAS · Crystal structure of PX domain of human sorting nexin SNX27 · the same entry in another collection · chain A against A, TM-score 1.00
Q96L92 · AlphaFold monomer V2.0 prediction for sorting nexin-27 (Q96L92) · a predicted model of the same protein · chain A against A, TM-score 0.96

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt Q96L92
Elsewhere: RCSB PDB 4HAS · PDBe 4HAS · UniProt Q96L92

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