MolNFT v1 · #92320 · protein
Crystal structure of Q61L H-RAS-gppnhp bound to the rbd of RAF kinase
4G3X · GTPase HRAS: “Crystal structure of Q61L H-RAS-gppnhp bound to the rbd of RAF kinase”. X-ray diffraction, 2 ligands (GNP, MG), 2 pockets (best druggability 0.67). MolNFT v1 #92320 on GenesisL1: 3D structure, binding sites and pockets…
- PDB
- 4G3X
- Type
- protein
- Length
- 243 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- GTPase HRAS; RAF proto-oncogene SERINE/THREONINE-protein kinase
- EC
- 2.7.11.1
- UniProt
- P01112, P04049
- Ligands
- GNP, MG
- Pockets
- 2 · best druggability 0.67
Structure
x-ray diffraction · 2 distinct chains · 24% helix, 23% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | GTPase HRAS | protein | 166 | 30% helix, 20% strand | P01112 |
| B | RAF proto-oncogene SERINE/THREONINE-protein kinase (EC 2.7.11.1) | protein | 77 | 12% helix, 31% strand | P04049 |
Ligands and binding sites
- GNP · Phosphoaminophosphonic acid-guanylate ester · ligand · chains A
- MG · Magnesium ion · metal · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 320 | 0.67 | 0.82 | 50 | GNP |
| 2 | 75 | 0.40 | 0.79 | 13 | empty |
Interfaces
1 interface between chains.
- A–B · 578 Ų buried · 9 hydrogen bonds · protein-protein
Compared structures
- 4G3X · Crystal Structure of Q61L H-Ras-GppNHp bound to the RBD of Raf Kinase · the same entry in another collection · chain A against A, TM-score 1.00
- P04049 · AlphaFold monomer V2.0 prediction for RAF proto-oncogene SERINE/THREONINE-protein kinase… · a predicted model of the same protein · chain B against A, TM-score 0.94
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P01112
- Every structure of UniProt P04049
- Elsewhere: RCSB PDB 4G3X · PDBe 4G3X · UniProt P01112 · UniProt P04049
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.