UniProt P04049
RAF proto-oncogene serine/threonine-protein kinase (P04049)
RAF proto-oncogene serine/threonine-protein kinase (UniProt P04049), EC 2.7.11.1: 67 experimental structures on GenesisL1, 10 ligands bound, 57 pockets. Binding sites, pockets, druggability and 3D structures in GL1X.
- UniProt
- P04049
- Protein
- RAF proto-oncogene serine/threonine-protein kinase
- EC
- 2.7.11.1
- Experimental structures
- 67
- Predicted models
- 0
- Ligands
- 10
- Pockets
- 57 · 13 records with a druggable one
Structures
67 records of P04049 in the MolNFT archive: 67 experimental, 0 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1C1Y | Crystal structure of RAP.GMPPNP in complex with the RAS-binding-domain of C-RAF1 kinase (rafrbd). | x-ray diffraction | B | — | — |
| 1C1Y | Crystal structure of RAP.GMPPNP in complex with the RAS- binding-domain of C-RAF1 kinase (rafrbd). | x-ray diffraction | B | — | — |
| 1FAQ | RAF-1 cysteine rich domain, NMR, 27 structures | solution nmr | A | — | — |
| 1FAQ | RAF-1 cysteine rich domain, NMR, 27 structures | solution nmr | A | — | — |
| 1FAR | RAF-1 cysteine rich domain, NMR, minimized average structure | solution nmr | A | — | — |
| 1FAR | RAF-1 cysteine rich domain, NMR, minimized average structure | solution nmr | A | — | — |
| 1GUA | Human RAP1A, residues 1-167, double mutant (E30D,K31E) complexed with gppnhp and the… | x-ray diffraction | B | — | — |
| 1GUA | Human RAP1A, residues 1-167, double mutant (E30D,K31E) complexed with gppnhp and the… | x-ray diffraction | B | — | — |
| 1RFA | NMR solution structure of the RAS-binding domain of C-RAF-1 | solution nmr | A | — | — |
| 1RFA | NMR solution structure of the RAS-binding domain of C-RAF-1 | solution nmr | A | — | — |
| 3CU8 | Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome | x-ray diffraction | P, Q | — | — |
| 3CU8 | Impaired binding of 14-3-3 to RAF1 is linked to noonan and leopard syndrome | x-ray diffraction | P, Q | — | — |
| 3IQJ | Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (10mer) | x-ray diffraction | P | — | — |
| 3IQJ | Crystal structure of human 14-3-3 sigma in complex with RAF1 peptide (10MER) | x-ray diffraction | P | — | — |
| 3IQU | Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer) | x-ray diffraction | P | — | — |
| 3IQU | Crystal structure of human 14-3-3 sigma in complex with RAF1 peptide (6MER) | x-ray diffraction | P | — | — |
| 3IQV | Crystal Structure of human 14-3-3 sigma in Complex with Raf1 peptide (6mer) and stabilisator… | x-ray diffraction | P | — | — |
| 3IQV | Crystal structure of human 14-3-3 sigma in complex with RAF1 peptide (6MER) and stabilisator… | x-ray diffraction | P | — | — |
| 3KUC | Complex of Rap1A(E30D/K31E)GDP with RafRBD(A85K/N71R) | x-ray diffraction | B | — | — |
| 3KUC | Complex of RAP1A(E30D/K31E)GDP with RAFRBD(A85K/N71R) | x-ray diffraction | B | — | — |
| 3KUD | Complex of Ras-GDP with RafRBD(A85K) | x-ray diffraction | B | — | — |
| 3KUD | Complex of RAS-GDP with RAFRBD(A85K) | x-ray diffraction | B | — | — |
| 3NKX | Impaired binding of 14-3-3 to Raf1 is linked to Noonan and LEOPARD syndrome | x-ray diffraction | P, Q | — | — |
| 3NKX | Impaired binding of 14-3-3 to RAF1 is linked to noonan and leopard syndrome | x-ray diffraction | P, Q | — | — |
| 3O8I | Structure of 14-3-3 isoform sigma in complex with a C-Raf1 peptide and a stabilizing small molecule… | x-ray diffraction | B | — | — |
| 3O8I | Structure of 14-3-3 isoform sigma in complex with a C-RAF1 peptide and a stabilizing small molecule… | x-ray diffraction | B | — | — |
| 3OMV | Crystal structure of c-raf (raf-1) | x-ray diffraction | A, B | — | — |
| 3OMV | Crystal structure of C-RAF (RAF-1) | x-ray diffraction | A, B | — | — |
| 4FJ3 | 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide | x-ray diffraction | P | — | — |
| 4FJ3 | 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide | x-ray diffraction | P | — | — |
| 4G0N | Crystal Structure of wt H-Ras-GppNHp bound to the RBD of Raf Kinase | x-ray diffraction | B | — | — |
| 4G0N | Crystal structure of wt H-RAS-gppnhp bound to the rbd of RAF kinase | x-ray diffraction | B | — | — |
| 4G3X | Crystal Structure of Q61L H-Ras-GppNHp bound to the RBD of Raf Kinase | x-ray diffraction | B | — | — |
| 4G3X | Crystal structure of Q61L H-RAS-gppnhp bound to the rbd of RAF kinase | x-ray diffraction | B | — | — |
| 4IEA | 14-3-3 isoform sigma in complex with a phosphorylated C-RAF peptide | x-ray diffraction | P | — | — |
| 4IEA | 14-3-3 isoform sigma in complex with a phosphorylated C-RAF peptide | x-ray diffraction | P | — | — |
| 4IHL | Human 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide and Cotylenin A | x-ray diffraction | P | — | — |
| 4IHL | Human 14-3-3 isoform zeta in complex with a diphoyphorylated C-RAF peptide and cotylenin a | x-ray diffraction | P | — | — |
| 6NTC | Crystal structure of G12V HRAS-gppnhp bound in complex with the engineered rbd variant 1 of craf… | x-ray diffraction | B | — | — |
| 6NTD | Crystal Structure of G12V HRas-GppNHp bound in complex with the engineered RBD variant 12 of CRAF… | x-ray diffraction | B | — | — |
| 6NTD | Crystal structure of G12V HRAS-gppnhp bound in complex with the engineered rbd variant 12 of craf… | x-ray diffraction | B | — | — |
| 6PTS | NMR data-driven model of KRAS-GMPPNP:RBD-crd complex tethered to a nanodisc (state a) | solution nmr | D | PCW, 17F, ZN | — |
| 6PTW | NMR data-driven model of KRas-GMPPNP:RBD-CRD complex tethered to a nanodisc (state B) | solution nmr | D | PCW, 17F, ZN | — |
| 6PTW | NMR data-driven model of KRAS-GMPPNP:RBD-crd complex tethered to a nanodisc (state B) | solution nmr | D | PCW, 17F, ZN | — |
| 6VJJ | Crystal structure of wild-type KRAS4B (gmppnp-bound) in complex with RAS-binding domain (rbd) of… | x-ray diffraction | B | — | — |
| 6XGU | Crystal structure of KRAS-Q61R (gmppnp-bound) in complex with RAS- binding domain (rbd) and… | x-ray diffraction | B | ZN | — |
| 6XGV | Crystal structure of KRAS-G13D (gmppnp-bound) in complex with RAS- binding domain (rbd) and… | x-ray diffraction | B | CL, ZN | — |
| 6XHA | Crystal structure of KRAS-G12V (gmppnp-bound) in complex with RAS- binding domain (rbd) and… | x-ray diffraction | B | ZN, CL | — |
| 6XHB | Crystal Structure of wild-type KRAS (GMPPNP-bound) in complex with RAS-binding domain (RBD) and… | x-ray diffraction | B | CL, ZN | — |
| 6XHB | Crystal structure of wild-type KRAS (gmppnp-bound) in complex with RAS-binding domain (rbd) and… | x-ray diffraction | B | CL, ZN | — |
| 6XI7 | Crystal Structure of wild-type KRAS (GMPPNP-bound) in complex with RAS-binding domain (RBD) and… | x-ray diffraction | B | ZN, CL | 1 (best 0.68) |
| 6XI7 | Crystal structure of wild-type KRAS (gmppnp-bound) in complex with RAS-binding domain (rbd) and… | x-ray diffraction | B | ZN, CL | — |
| 7JHP | Crystal structure of HRAS in complex with the RAS-binding and cysteine-rich domains of craf-kinase | x-ray diffraction | C | ZN | — |
| 7Z37 | Structure of the RAF1-HSP90-CDC37 complex (RHC-II) | electron microscopy | CP1 | — | 10 (best 0.84) |
| 7Z38 | Structure of the RAF1-HSP90-CDC37 complex (RHC-I) | electron microscopy | C | — | 8 (best 0.84) |
| 8A68 | Small molecule stabilizer (compound 5) for C-RAF(pS259) and 14-3-3 | x-ray diffraction | B | L7U | 2 (best 0.63) |
| 8A6F | Small molecule stabilizer (compound 8) for C-RAF and 14-3-3 | x-ray diffraction | P | O56 | 2 (best 0.62) |
| 8A6H | Small molecule stabilizer (compound 7) for C-RAF and 14-3-3 | x-ray diffraction | P | L6L | 2 (best 0.64) |
| 8ATR | Small molecular stabilizer for C-RAF (pS259) and 14-3-3 (1075297) | x-ray diffraction | P | O6L | 2 (best 0.59) |
| 8AV0 | small molecule stabilizer (compound 1) for C-RAF pS259 and 14-3-3 | x-ray diffraction | P | O6C | 2 (best 0.62) |
7 records more on the page itself.
Ligands
- ZN · Zinc ion · in 11 records
- CL · Chloride ion · in 6 records
- 17F · O-[(S)-({(2R)-2,3-bis[(9Z)-octadec-9-enoyloxy]propyl}oxy)(hydroxy)phosphoryl]-L-serine · in 3 records
- PCW · 1,2-dioleoyl-sn-glycero-3-phosphocholine · in 3 records
- A1AHE · N-[3-fluoro-4-({7-[(3-fluoropyridin-2-yl)oxy]-4-methyl-2-oxo-2H-1-benzopyran-3-yl}methyl)pyridin-2-yl]-N'-methylsulfuric diamide · in 1 record
- L6L · 3-[2-(dimethylamino)ethyldisulfanyl]-1-[4-oxidanyl-4-[3-(trifluoromethyl)phenyl]piperidin-1-yl]propan-1-one · in 1 record
- L7U · ~{N}-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]-1-[(2~{R})-2-(6-methoxynaphthalen-2-yl)propanoyl]piperidine-4-carboxamide · in 1 record
- O56 · 1-[4-[4-chloranyl-3-(trifluoromethyl)phenyl]-4-oxidanyl-piperidin-1-yl]-3-[2-(dimethylamino)ethyldisulfanyl]propan-1-one · in 1 record
- O6C · 1-[2-(4-chloranylphenoxy)-2-methyl-propanoyl]-~{N}-[2-[2-(dimethylamino)ethyldisulfanyl]ethyl]piperidine-4-carboxamide · in 1 record
- O6L · 2-chloranyl-~{N}-[[1-[1-(4-chloranylphenoxy)cyclopentyl]carbonylpiperidin-4-yl]methyl]ethanamide · in 1 record
Elsewhere
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.