MolNFT v1 · #92146 · protein
Crystal structure of spleen tyrosine kinase complexed with N-{(S)-1- [7-(3,4-dimethoxy-phenylamino)-THIAZOLO[5,4-D]PYRIMIDIN-5-yl]- pyrrolidin-3-yl}-terephthalamic acid
4FYO · Tyrosine-protein kinase syk: “Crystal structure of spleen tyrosine kinase complexed with N-{(S)-1…”. X-ray diffraction, 1 ligand (0VF), 2 pockets (best druggability 0.62). MolNFT v1 #92146 on GenesisL1: 3D structure, binding sites…
- PDB
- 4FYO
- Type
- protein
- Length
- 267 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Tyrosine-protein kinase syk
- EC
- 2.7.10.2
- UniProt
- P43405
- Ligands
- 0VF
- Pockets
- 2 · best druggability 0.62
Structure
x-ray diffraction · 1 distinct chain · 42% helix, 20% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Tyrosine-protein kinase syk (EC 2.7.10.2) | protein | 267 | 42% helix, 20% strand | P43405 |
Ligands and binding sites
- 0VF · 4-{[(3S)-1-{7-[(3,4-dimethoxyphenyl)amino][1,3]thiazolo[5,4-d]pyrimidin-5-yl}pyrrolidin-3-yl]carbamoyl}benzoic acid · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 207 | 0.62 | 0.82 | 30 | 0VF |
| 2 | 54 | 0.29 | 0.75 | 13 | empty |
Compared structures
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P43405
- Elsewhere: RCSB PDB 4FYO · PDBe 4FYO · UniProt P43405
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