MolNFT v1 · #91440 · protein
Crystal structure of the E493V mutant of human apoptosis inducing factor (aif)
4FDC · Apoptosis-inducing factor 1, mitochondrial: “Crystal structure of the E493V mutant of human apoptosis inducing factor (aif)”. X-ray diffraction, 1 ligand (FAD), 3 pockets (best druggability 0.82). MolNFT v1 #91440 on GenesisL1: 3D…
- PDB
- 4FDC
- Type
- protein
- Length
- 461 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Apoptosis-inducing factor 1, mitochondrial
- EC
- 1.-.-.-
- UniProt
- O95831
- Ligands
- FAD
- Pockets
- 3 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 27% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Apoptosis-inducing factor 1, mitochondrial (EC 1.-.-.-) | protein | 461 | 27% helix, 30% strand | O95831 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 977 | 0.82 | 0.83 | 88 | FAD |
| 2 | 63 | 0.32 | 0.76 | 18 | empty |
| 3 | 54 | 0.26 | 0.74 | 16 | empty |
Compared structures
- 4FDC · Crystal structure of the E493V mutant of human apoptosis inducing factor (AIF) · the same entry in another collection · chain B against B, TM-score 1.00
- O95831 · AlphaFold monomer V2.0 prediction for apoptosis-inducing factor 1, mitochondrial (O95831) · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95831
- Elsewhere: RCSB PDB 4FDC · PDBe 4FDC · UniProt O95831
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