Research workbench
Crystal structure of the E493V mutant of human apoptosis inducing factor (aif)
Analyse Crystal structure of the E493V mutant of human apoptosis inducing factor (aif) in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4FDC
- Type
- protein
- Length
- 461 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Apoptosis-inducing factor 1, mitochondrial
- EC
- 1.-.-.-
- UniProt
- O95831
- Ligands
- FAD
- Pockets
- 3 · best druggability 0.82
Structure
x-ray diffraction · 1 distinct chain · 27% helix, 30% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Apoptosis-inducing factor 1, mitochondrial (EC 1.-.-.-) | protein | 461 | 27% helix, 30% strand | O95831 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 977 | 0.82 | 0.83 | 88 | FAD |
| 2 | 63 | 0.32 | 0.76 | 18 | empty |
| 3 | 54 | 0.26 | 0.74 | 16 | empty |
Compared structures
- 4FDC · Crystal structure of the E493V mutant of human apoptosis inducing factor (AIF) · the same entry in another collection · chain B against B, TM-score 1.00
- O95831 · AlphaFold monomer V2.0 prediction for apoptosis-inducing factor 1, mitochondrial (O95831) · a predicted model of the same protein · chain B against A, TM-score 1.00
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95831
- Elsewhere: RCSB PDB 4FDC · PDBe 4FDC · UniProt O95831
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