UniProt O95831
Apoptosis-inducing factor 1, mitochondrial (O95831)
Apoptosis-inducing factor 1, mitochondrial (UniProt O95831), EC 1.1.1.-, 1.6.99.-: 32 experimental structures and 1 predicted model on GenesisL1, 10 ligands bound, 89 pockets. Binding sites, druggability and experiment against…
- UniProt
- O95831
- Protein
- Apoptosis-inducing factor 1, mitochondrial
- EC
- 1.1.1.-, 1.6.99.-
- Experimental structures
- 32
- Predicted models
- 1
- Ligands
- 10
- Pockets
- 89 · 12 records with a druggable one
Structures
33 records of O95831 in the MolNFT archive: 32 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1M6I | Crystal Structure of Apoptosis Inducing Factor (AIF) | x-ray diffraction | A | FAD | 3 (best 0.82) |
| 1M6I | Crystal structure of apoptosis inducing factor (aif) | x-ray diffraction | A | — | — |
| 4BUR | Crystal structure of the reduced human Apoptosis inducing factor complexed with NAD | x-ray diffraction | A, B, C, D | — | — |
| 4BUR | Crystal structure of the reduced human apoptosis inducing factor complexed with NAD | x-ray diffraction | A, B, C, D | — | — |
| 4BV6 | Refined crystal structure of the human Apoptosis inducing factor | x-ray diffraction | A | — | — |
| 4BV6 | Refined crystal structure of the human apoptosis inducing factor | x-ray diffraction | A | — | — |
| 4FDC | Crystal structure of the E493V mutant of human apoptosis inducing factor (AIF) | x-ray diffraction | B | — | — |
| 4FDC | Crystal structure of the E493V mutant of human apoptosis inducing factor (aif) | x-ray diffraction | B | — | — |
| 4LII | Crystal structure of an apoptosis-inducing factor, mitochondrion-associated, 1 (AIFM1) from Homo… | x-ray diffraction | A | — | — |
| 4LII | Crystal structure of an apoptosis-inducing factor, mitochondrion- associated, 1 (AIFM1) from homo… | x-ray diffraction | A | — | — |
| 5FMH | Crystal structure of the E405K mutant of human apoptosis inducing factor | x-ray diffraction | A | FAD | — |
| 5FMH | Crystal structure of the E405K mutant of human apoptosis inducing factor | x-ray diffraction | A | — | — |
| 5FS6 | Crystal structure of the V243L mutant of human apoptosis inducing factor | x-ray diffraction | A, B | — | — |
| 5FS6 | Crystal structure of the V243L mutant of human apoptosis inducing factor | x-ray diffraction | A, B | — | — |
| 5FS7 | Crystal structure of the G262S mutant of human apoptosis inducing factor | x-ray diffraction | A, B | FAD | 9 (best 0.82) |
| 5FS7 | Crystal structure of the G262S mutant of human apoptosis inducing factor | x-ray diffraction | A, B | — | — |
| 5FS8 | Crystal structure of the G308E mutant of human apoptosis inducing factor | x-ray diffraction | A | FAD | 3 (best 0.82) |
| 5FS8 | Crystal structure of the G308E mutant of human apoptosis inducing factor | x-ray diffraction | A | — | — |
| 5FS9 | Crystal structure of the G338E mutant of human apoptosis inducing factor | x-ray diffraction | A, B | FAD | 11 (best 0.82) |
| 5FS9 | Crystal structure of the G338E mutant of human apoptosis inducing factor | x-ray diffraction | A, B | — | — |
| 5KVH | Crystal structure of human apoptosis-inducing factor with W196A mutation | x-ray diffraction | A, B | FAD | — |
| 5KVH | Crystal structure of human apoptosis-inducing factor with W196A mutation | x-ray diffraction | A, B | FAD | — |
| 5KVI | Crystal structure of monomeric human apoptosis-inducing factor with E413A/R422A/R430A mutations | x-ray diffraction | A | FAD | — |
| 5KVI | Crystal structure of monomeric human apoptosis-inducing factor with E413A/R422A/R430A mutations | x-ray diffraction | A | FAD | — |
| 8D3E | Crystal structure of human Apoptosis-Inducing Factor (AIF) W196A mutant complexed with… | x-ray diffraction | A, B | FAD, QDI, CL | 9 (best 0.82) |
| 8D3G | Crystal structure of human Apoptosis-Inducing Factor (AIF) W196A mutant complexed with… | x-ray diffraction | A, B | FAD, QD1 | 7 (best 0.81) |
| 8D3H | Crystal structure of human Apoptosis-Inducing Factor (AIF) W196A mutant complexed with… | x-ray diffraction | A, B | FAD, QBC | 7 (best 0.82) |
| 8D3I | Crystal structure of human Apoptosis-Inducing Factor (AIF) W196A mutant complexed with… | x-ray diffraction | A, B | 1LM, FAD, SO4 | 11 (best 0.81) |
| 8D3J | Crystal structure of human Apoptosis-Inducing Factor (AIF) complexed with… | x-ray diffraction | A, B | FAD, QEF, SO4 | 7 (best 0.82) |
| 8D3K | Crystal structure of human Apoptosis-Inducing Factor (AIF) complexed with… | x-ray diffraction | A, B | QC6, FAD, SO4 | 6 (best 0.81) |
| 8D3N | Crystal structure of human Apoptosis-Inducing Factor (AIF) complexed with 7-chloroquinolin-4-amine | x-ray diffraction | A, B | QBC, FAD, SO4 | 8 (best 0.82) |
| 8D3O | Crystal structure of human Apoptosis-Inducing Factor (AIF) complexed with 8-methoxyquinolin-4-amine | x-ray diffraction | A, B | QF6, FAD, SO4 | 8 (best 0.82) |
| O95831 | AlphaFold monomer V2.0 prediction for apoptosis-inducing factor 1, mitochondrial (O95831) | predicted | A | — | — |
Ligands
- FAD · Flavin-adenine dinucleotide · in 17 records
- SO4 · Sulfate ion · in 5 records
- QBC · 7-chloroquinolin-4-amine · in 2 records
- 1LM · quinolin-4-amine · in 1 record
- CL · Chloride ion · in 1 record
- QC6 · 8-fluoro-2-methylquinolin-4-amine · in 1 record
- QD1 · 6-chloroquinolin-4-amine · in 1 record
- QDI · 6-fluoroquinolin-4-amine · in 1 record
- QEF · 6-fluoro-2-methylquinolin-4-amine · in 1 record
- QF6 · 8-methoxyquinolin-4-amine · in 1 record
Experiment against prediction
- 4BV6 chain A against the predicted model O95831: TM-score 1.00, RMSD 0.23 Å
- 4BV6 chain A against the predicted model O95831: TM-score 1.00, RMSD 0.23 Å
- 4LII chain A against the predicted model O95831: TM-score 1.00, RMSD 0.24 Å
- 4LII chain A against the predicted model O95831: TM-score 1.00, RMSD 0.24 Å
- 1M6I chain A against the predicted model O95831: TM-score 1.00, RMSD 0.24 Å
- 1M6I chain A against the predicted model O95831: TM-score 1.00, RMSD 0.24 Å
- 5FS8 chain A against the predicted model O95831: TM-score 1.00, RMSD 0.33 Å
- 5FS8 chain A against the predicted model O95831: TM-score 1.00, RMSD 0.33 Å
- 4FDC chain B against the predicted model O95831: TM-score 1.00, RMSD 0.50 Å
- 4FDC chain B against the predicted model O95831: TM-score 1.00, RMSD 0.50 Å
Elsewhere
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