MolNFT v1 · #119119 · protein
Crystal structure of the E405K mutant of human apoptosis inducing factor
5FMH · Apoptosis-inducing factor 1, mitochondrial: “Crystal structure of the E405K mutant of human apoptosis inducing factor”. X-ray diffraction, 1 ligand (FAD), 2 pockets (best druggability 0.81). MolNFT v1 #119119 on GenesisL1: 3D…
- PDB
- 5FMH
- Type
- protein
- Length
- 472 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Apoptosis-inducing factor 1, mitochondrial
- UniProt
- O95831
- Ligands
- FAD
- Pockets
- 2 · best druggability 0.81
Structure
x-ray diffraction · 1 distinct chain · 29% helix, 29% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Apoptosis-inducing factor 1, mitochondrial | protein | 472 | 29% helix, 29% strand | O95831 |
Ligands and binding sites
- FAD · Flavin-adenine dinucleotide · ligand · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
2 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1020 | 0.81 | 0.82 | 89 | FAD |
| 2 | 98 | 0.40 | 0.77 | 16 | empty |
Compared structures
- 5FMH · Crystal structure of the E405K mutant of human apoptosis inducing factor · the same entry in another collection · chain A against A, TM-score 1.00
- O95831 · AlphaFold monomer V2.0 prediction for apoptosis-inducing factor 1, mitochondrial (O95831) · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt O95831
- Elsewhere: RCSB PDB 5FMH · PDBe 5FMH · UniProt O95831
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