MolNFT v1 · #88601 · protein
Structure of the neurospora crassa PAN2 catalytic unit (protease and nuclease domain)
4CZW · Pab-dependent POLY(A)-specific ribonuclease subunit PAN2: “Structure of the neurospora crassa PAN2 catalytic unit (protease and nuclease domain)”. X-ray diffraction, 1 ligand (ZN), 10 pockets (best druggability 0.78). MolNFT v1…
- PDB
- 4CZW
- Type
- protein
- Length
- 609 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pab-dependent POLY(A)-specific ribonuclease subunit PAN2
- EC
- 3.1.13.4
- UniProt
- P0C581
- Ligands
- ZN
- Pockets
- 10 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 33% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pab-dependent POLY(A)-specific ribonuclease subunit PAN2 (EC 3.1.13.4) | protein | 609 | 33% helix, 24% strand | P0C581 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 130 | 0.78 | 0.96 | 26 | empty |
| 2 | 324 | 0.62 | 0.79 | 32 | empty |
| 3 | 308 | 0.60 | 0.78 | 32 | empty |
| 4 | 252 | 0.56 | 0.77 | 25 | empty |
| 5 | 133 | 0.48 | 0.78 | 26 | empty |
Modifications
Observed in the structure: 11 modified (engineered).
Compared structures
- 4CZW · Structure of the Neurospora crassa Pan2 catalytic unit (protease and nuclease domain) · the same entry in another collection · chain A against A, TM-score 1.00
- P0C581 · AlphaFold monomer V2.0 prediction for PAN2-PAN3 deadenylation complex catalytic subunit… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0C581
- Elsewhere: RCSB PDB 4CZW · PDBe 4CZW · UniProt P0C581
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