Research workbench
Structure of the neurospora crassa PAN2 catalytic unit (protease and nuclease domain)
Analyse Structure of the neurospora crassa PAN2 catalytic unit (protease and nuclease… in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4CZW
- Type
- protein
- Length
- 609 residues
- Chains
- 1
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Pab-dependent POLY(A)-specific ribonuclease subunit PAN2
- EC
- 3.1.13.4
- UniProt
- P0C581
- Ligands
- ZN
- Pockets
- 10 · best druggability 0.78
Structure
x-ray diffraction · 1 distinct chain · 33% helix, 24% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Pab-dependent POLY(A)-specific ribonuclease subunit PAN2 (EC 3.1.13.4) | protein | 609 | 33% helix, 24% strand | P0C581 |
Ligands and binding sites
- ZN · Zinc ion · metal · 2 copies · chains A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
10 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 130 | 0.78 | 0.96 | 26 | empty |
| 2 | 324 | 0.62 | 0.79 | 32 | empty |
| 3 | 308 | 0.60 | 0.78 | 32 | empty |
| 4 | 252 | 0.56 | 0.77 | 25 | empty |
| 5 | 133 | 0.48 | 0.78 | 26 | empty |
Modifications
Observed in the structure: 11 modified (engineered).
Compared structures
- 4CZW · Structure of the Neurospora crassa Pan2 catalytic unit (protease and nuclease domain) · the same entry in another collection · chain A against A, TM-score 1.00
- P0C581 · AlphaFold monomer V2.0 prediction for PAN2-PAN3 deadenylation complex catalytic subunit… · a predicted model of the same protein · chain A against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0C581
- Elsewhere: RCSB PDB 4CZW · PDBe 4CZW · UniProt P0C581
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