MolNFT v1 · #286419 · protein
AlphaFold monomer V2.0 prediction for PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (P0C581)
P0C581: “AlphaFold monomer V2.0 prediction for PAN2-PAN3 deadenylation complex catalytic subunit PAN2 (P0C581)”. 13 pockets (best druggability 0.82). MolNFT v1 #286419 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- Accession
- P0C581
- Type
- protein
- Length
- 1,310 residues
- Chains
- 1
- Collection
- MolNFT v1 / AlphaFold
- Contract
- 0xBf7491af3407816DFa88a5EA4c82e8A2B1D721eD
- Owner
- 0x4BC59faea63ACA4315D24e40823D4B8bF16F1540
- Molecule
- PAN2-PAN3 deadenylation complex catalytic subunit PAN2
- UniProt
- P0C581
- Pockets
- 13 · best druggability 0.82
Structure
1 distinct chain · 21% helix, 26% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | PAN2-PAN3 deadenylation complex catalytic subunit PAN2 | protein | 1310 | 21% helix, 26% strand | P0C581 |
Pockets
13 pockets found on a 1 Å grid, 6 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1066 | 0.82 | 0.83 | 72 | empty |
| 2 | 839 | 0.76 | 0.80 | 56 | empty |
| 3 | 325 | 0.63 | 0.80 | 32 | empty |
| 4 | 152 | 0.54 | 0.80 | 22 | empty |
| 5 | 295 | 0.52 | 0.74 | 38 | empty |
Compared structures
- 4CZW · Structure of the Neurospora crassa Pan2 catalytic unit (protease and nuclease domain) · an experimental structure of the same protein · chain A against A, TM-score 0.46
- 4CZW · Structure of the neurospora crassa PAN2 catalytic unit (protease and nuclease domain) · an experimental structure of the same protein · chain A against A, TM-score 0.46
- 4CZX · Complex of Neurospora crassa PAN2 (WD40) with PAN3 (C-TERM) · an experimental structure of the same protein · chain A against A, TM-score 0.24
- 4CZX · Complex of neurospora crassa PAN2 (WD40) with PAN3 (C-term) · an experimental structure of the same protein · chain A against A, TM-score 0.24
- 4CZY · Complex of neurospora crassa PAN2 (WD40-CS1) with PAN3 (pseudokinase and C-term) · an experimental structure of the same protein · chain A against A, TM-score 0.24
- 4CZY · Complex of Neurospora crassa PAN2 (WD40-CS1) with PAN3 (pseudokinase and C-term) · an experimental structure of the same protein · chain A against A, TM-score 0.24
- 4CZV · Structure of the Neurospora crassa Pan2 WD40 domain · an experimental structure of the same protein · chain A against A, TM-score 0.24
- 4CZV · Structure of the neurospora crassa PAN2 WD40 domain · an experimental structure of the same protein · chain A against A, TM-score 0.24
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P0C581
- Elsewhere: UniProt P0C581 · AlphaFold DB P0C581
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