MolNFT v1 · #87495 · protein

NUP1:SAC3:SUS1 complex

4C31 · Nuclear mRNA export protein SAC3: “NUP1:SAC3:SUS1 complex”. X-ray diffraction, 3 pockets (best druggability 0.70). MolNFT v1 #87495 on GenesisL1: 3D structure, binding sites and pockets in GL1X.

PDB: 4C31
Type: protein
Length: 286 residues
Chains: 8
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Nuclear mRNA export protein SAC3; Protein SUS1; Nucleoporin NUP1
UniProt: P46674, Q6WNK7, P20676
Pockets: 3 · best druggability 0.70

Structure

x-ray diffraction · 6 distinct chains · 64% helix, 3% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A, D	Nuclear mRNA export protein SAC3	protein	31	90% helix, 0% strand	P46674
B, E	Protein SUS1	protein	92	83% helix, 1% strand	Q6WNK7
C	Nucleoporin NUP1	protein	15	0% helix, 7% strand	P20676
F	Nucleoporin NUP1	protein	14	0% helix, 7% strand	P20676
X	Nucleoporin NUP1	protein	5	0% helix, 20% strand	P20676
Y	Nucleoporin NUP1	protein	6	0% helix, 17% strand	P20676

Pockets

3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	304	0.70	0.83	38	empty
2	132	0.40	0.74	28	empty
3	55	0.30	0.75	13	empty

Interfaces

18 interfaces between chains.

A–B · 1543 Å² buried · 11 hydrogen bonds · protein-protein
D–E · 1542 Å² buried · 13 hydrogen bonds · protein-protein
E–F · 468 Å² buried · 1 hydrogen bond · protein-protein
B–C · 467 Å² buried · 1 hydrogen bond · protein-protein
B–E · 403 Å² buried · 4 hydrogen bonds · protein-protein

Compared structures

4C31 · Nup1:Sac3:Sus1 complex · the same entry in another collection · chain Y against Y, TM-score 1.00
P46674 · AlphaFold monomer V2.0 prediction for nuclear mRNA export protein SAC3 (P46674) · a predicted model of the same protein · chain A against A, TM-score 0.90
P20676 · AlphaFold monomer V2.0 prediction for nucleoporin NUP1 (P20676) · a predicted model of the same protein · chain X against A, TM-score 0.83
Q6WNK7 · AlphaFold monomer V2.0 prediction for transcription and mRNA export factor SUS1 (Q6WNK7) · a predicted model of the same protein · chain B against A, TM-score 0.77

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P46674
Every structure of UniProt Q6WNK7
Every structure of UniProt P20676
Elsewhere: RCSB PDB 4C31 · PDBe 4C31 · UniProt P46674 · UniProt Q6WNK7 · UniProt P20676

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