Research workbench
NUP1:SAC3:SUS1 complex
Analyse NUP1:SAC3:SUS1 complex in the GL1X research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides, crosslinks and neighbours on the 3D structure.
- PDB
- 4C31
- Type
- protein
- Length
- 286 residues
- Chains
- 8
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Nuclear mRNA export protein SAC3; Protein SUS1; Nucleoporin NUP1
- UniProt
- P46674, Q6WNK7, P20676
- Pockets
- 3 · best druggability 0.70
Structure
x-ray diffraction · 6 distinct chains · 64% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A, D | Nuclear mRNA export protein SAC3 | protein | 31 | 90% helix, 0% strand | P46674 |
| B, E | Protein SUS1 | protein | 92 | 83% helix, 1% strand | Q6WNK7 |
| C | Nucleoporin NUP1 | protein | 15 | 0% helix, 7% strand | P20676 |
| F | Nucleoporin NUP1 | protein | 14 | 0% helix, 7% strand | P20676 |
| X | Nucleoporin NUP1 | protein | 5 | 0% helix, 20% strand | P20676 |
| Y | Nucleoporin NUP1 | protein | 6 | 0% helix, 17% strand | P20676 |
Pockets
3 pockets found on a 1 Å grid, 1 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 304 | 0.70 | 0.83 | 38 | empty |
| 2 | 132 | 0.40 | 0.74 | 28 | empty |
| 3 | 55 | 0.30 | 0.75 | 13 | empty |
Interfaces
18 interfaces between chains.
- A–B · 1543 Ų buried · 11 hydrogen bonds · protein-protein
- D–E · 1542 Ų buried · 13 hydrogen bonds · protein-protein
- E–F · 468 Ų buried · 1 hydrogen bond · protein-protein
- B–C · 467 Ų buried · 1 hydrogen bond · protein-protein
- B–E · 403 Ų buried · 4 hydrogen bonds · protein-protein
Compared structures
- 4C31 · Nup1:Sac3:Sus1 complex · the same entry in another collection · chain Y against Y, TM-score 1.00
- P46674 · AlphaFold monomer V2.0 prediction for nuclear mRNA export protein SAC3 (P46674) · a predicted model of the same protein · chain A against A, TM-score 0.90
- P20676 · AlphaFold monomer V2.0 prediction for nucleoporin NUP1 (P20676) · a predicted model of the same protein · chain X against A, TM-score 0.83
- Q6WNK7 · AlphaFold monomer V2.0 prediction for transcription and mRNA export factor SUS1 (Q6WNK7) · a predicted model of the same protein · chain B against A, TM-score 0.77
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt P46674
- Every structure of UniProt Q6WNK7
- Every structure of UniProt P20676
- Elsewhere: RCSB PDB 4C31 · PDBe 4C31 · UniProt P46674 · UniProt Q6WNK7 · UniProt P20676
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