Crystal structure of a RAVER1 PRI4 peptide in complex with polypyrimidine tract binding protein RRM2

Structure

x-ray diffraction · 2 distinct chains · 20% helix, 38% strand (DSSP).

Ligands and binding sites

• IOD · Iodide ion · ion · 5 copies · chains A, D

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

1 pocket found on a 1 Å grid, 1 with a druggability of 0.5 or more.

Interfaces

4 interfaces between chains.

• A–B · 452 Ų buried · 4 hydrogen bonds · protein-protein
• A–C · 416 Ų buried · 6 hydrogen bonds · protein-protein
• B–D · 387 Ų buried · 5 hydrogen bonds · protein-protein
• A–D · 137 Ų buried · 3 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 2 disulfide (disulfide).

Compared structures

• 3ZZZ · Crystal structure of a Raver1 PRI4 peptide in complex with polypyrimidine tract binding… · the same entry in another collection · chain A against A, TM-score 1.00
• P26599 · AlphaFold monomer V2.0 prediction for polypyrimidine tract-binding protein 1 (P26599) · a predicted model of the same protein · chain A against A, TM-score 0.98
• Q9CW46 · AlphaFold monomer V2.0 prediction for ribonucleoprotein ptb-binding 1 (Q9CW46) · a predicted model of the same protein · chain C against A, TM-score 0.62

Analyse

• Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
• Every structure of UniProt P26599
• Every structure of UniProt Q9CW46
• Elsewhere: RCSB PDB 3ZZZ · PDBe 3ZZZ · UniProt P26599 · UniProt Q9CW46