MolNFT v1 · #8035 · protein

Heterotrimeric complex of a gt-ALPHA/GI-alpha chimera and the gt-beta-gamma subunits

1GOT: “Heterotrimeric complex of a gt-ALPHA/GI-alpha chimera and the gt-beta-gamma subunits”. X-ray diffraction, 1 ligand (GDP), 4 pockets (best druggability 0.81). MolNFT v1 #8035 on GenesisL1: 3D structure, binding sites and pockets in…

PDB: 1GOT
Type: protein
Length: 735 residues
Chains: 3
Method: x-ray diffraction
Collection: MolNFT v1 / PDB
Contract: 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
Owner: 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
Molecule: Gt-ALPHA/GI-alpha chimera; Gt-beta; Gt-gamma
UniProt: P04695, P62871, P02698
Ligands: GDP
Pockets: 4 · best druggability 0.81

Structure

x-ray diffraction · 3 distinct chains · 33% helix, 29% strand (DSSP).

Chain	Molecule	Type	Residues	Secondary structure	UniProt
A	Gt-ALPHA/GI-alpha chimera	protein	338	53% helix, 14% strand	P04695
B	Gt-beta	protein	339	8% helix, 48% strand	P62871
G	Gt-gamma	protein	58	69% helix, 0% strand	P02698

Ligands and binding sites

GDP · Guanosine-5'-diphosphate · ligand · chains A

Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.

Pockets

4 pockets found on a 1 Å grid, 4 with a druggability of 0.5 or more.

Pocket	Volume (Å³)	Druggability	Buriedness	Lining residues	Inside
1	795	0.81	0.85	66	empty
2	896	0.76	0.79	80	GDP
3	398	0.63	0.78	59	empty
4	269	0.55	0.76	34	empty

Interfaces

2 interfaces between chains.

B–G · 2442 Å² buried · 27 hydrogen bonds · protein-protein
A–B · 1302 Å² buried · 22 hydrogen bonds · protein-protein

Modifications

Observed in the structure: 12 modified (engineered).

Compared structures

1GOT · Heterotrimeric complex of a gt-ALPHA/GI-alpha chimera and the gt-beta-gamma subunits · the same entry in another collection · chain A against A, TM-score 1.00
P62871 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(I)/G(S)/G(T)… · a predicted model of the same protein · chain B against A, TM-score 0.99
P04695 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(T) subunit… · a predicted model of the same protein · chain A against A, TM-score 0.95
P02698 · AlphaFold monomer V2.0 prediction for guanine nucleotide-binding protein G(T) subunit… · a predicted model of the same protein · chain G against A, TM-score 0.92

Analyse

Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
Every structure of UniProt P04695
Every structure of UniProt P62871
Every structure of UniProt P02698
Elsewhere: RCSB PDB 1GOT · PDBe 1GOT · UniProt P04695 · UniProt P62871 · UniProt P02698

GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.