MolNFT v1 · #75730 · protein
Crystal structure of FTASE(ALPHA-subunit; beta-subunit delta C10) in complex with BMS3 and lipid substrate fpp
3PZ4 · Protein FARNESYLTRANSFERASE/GERANYLGERANYLTRANSFERASE type…: “Crystal structure of FTASE(ALPHA-subunit; beta-subunit delta C10) in complex with BMS3 and lipid substrate fpp”. X-ray diffraction, 3 ligands (FPP, 3PZ, ZN), 13 pockets…
- PDB
- 3PZ4
- Type
- protein
- Length
- 718 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein FARNESYLTRANSFERASE/GERANYLGERANYLTRANSFERASE type- 1 subunit alpha; Protein…
- EC
- 2.5.1.58, 2.5.1.59
- UniProt
- Q04631, Q02293
- Ligands
- FPP, 3PZ, ZN
- Pockets
- 13 · best druggability 0.77
Structure
x-ray diffraction · 2 distinct chains · 59% helix, 4% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| A | Protein FARNESYLTRANSFERASE/GERANYLGERANYLTRANSFERASE type- 1 subunit alpha (EC 2.5.1.58, 2.5.1.59) | protein | 315 | 66% helix, 1% strand | Q04631 |
| B | Protein farnesyltransferase subunit beta (EC 2.5.1.58) | protein | 403 | 53% helix, 6% strand | Q02293 |
Ligands and binding sites
- FPP · Farnesyl diphosphate · ligand · chains A, B
- 3PZ · (3R)-3-benzyl-4-[(4-methoxyphenyl)sulfonyl]-1-[(1-methyl-1H-imidazol-5-yl)methyl]-2,3,4,5-tetrahydro-1H-1,4-benzodiazepine-7-carbonitrile · ligand · chains B
- ZN · Zinc ion · metal · chains B
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
13 pockets found on a 1 Å grid, 5 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 1043 | 0.77 | 0.79 | 74 | FPP, 3PZ |
| 2 | 264 | 0.73 | 0.87 | 41 | empty |
| 3 | 62 | 0.67 | 0.95 | 20 | empty |
| 4 | 144 | 0.55 | 0.82 | 20 | empty |
| 5 | 51 | 0.55 | 0.90 | 17 | empty |
Interfaces
1 interface between chains.
- A–B · 3498 Ų buried · 70 hydrogen bonds · protein-protein
Compared structures
- 3PZ4 · Crystal structure of FTase(ALPHA-subunit; BETA-subunit DELTA C10) in complex with BMS3… · the same entry in another collection · chain A against A, TM-score 1.00
- Q04631 · AlphaFold monomer V2.0 prediction for protein FARNESYLTRANSFERASE/GERANYLGERANYLTRANSFERAS… · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q02293 · AlphaFold monomer V2.0 prediction for protein farnesyltransferase subunit beta (Q02293) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q04631
- Every structure of UniProt Q02293
- Elsewhere: RCSB PDB 3PZ4 · PDBe 3PZ4 · UniProt Q04631 · UniProt Q02293
GL1X is a live explorer of the GenesisL1 blockchain. Turn on JavaScript for search, charts and interactive views.