UniProt Q02293
Protein farnesyltransferase subunit beta (Q02293)
Protein farnesyltransferase subunit beta (UniProt Q02293), EC 2.5.1.58: 89 experimental structures and 1 predicted model on GenesisL1, 8 ligands bound, 21 pockets. Binding sites, druggability and experiment against prediction…
- UniProt
- Q02293
- Protein
- Protein farnesyltransferase subunit beta
- EC
- 2.5.1.58
- Experimental structures
- 89
- Predicted models
- 1
- Ligands
- 8
- Pockets
- 21 · 2 records with a druggable one
Structures
90 records of Q02293 in the MolNFT archive: 89 experimental, 1 predicted.
| Entry | Title | Method | Chains | Ligands | Pockets |
|---|---|---|---|---|---|
| 1D8D | Co-crystal structure of rat protein farnesyltransferase complexed with a K-RAS4B peptide substrate… | x-ray diffraction | B | — | — |
| 1D8D | Co-crystal structure of rat protein farnesyltransferase complexed with a K-RAS4B peptide substrate… | x-ray diffraction | B | — | — |
| 1D8E | Zinc-depleted FTase complexed with K-RAS4B peptide substrate and FPP analog. | x-ray diffraction | B | — | — |
| 1D8E | Zinc-depleted ftase complexed with K-RAS4B peptide substrate and fpp analog. | x-ray diffraction | B | — | — |
| 1FPP | Protein farnesyltransferase complex with farnesyl diphosphate | x-ray diffraction | B | — | — |
| 1FPP | Protein farnesyltransferase complex with farnesyl diphosphate | x-ray diffraction | B | — | — |
| 1FT1 | Crystal structure of protein farnesyltransferase at 2.25 ångströms resolution | x-ray diffraction | B | — | — |
| 1FT1 | Crystal structure of protein farnesyltransferase at 2.25 ångströms resolution | x-ray diffraction | B | — | — |
| 1FT2 | Co-crystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate | x-ray diffraction | B | — | — |
| 1FT2 | Co-crystal structure of protein farnesyltransferase complexed with a farnesyl diphosphate substrate | x-ray diffraction | B | — | — |
| 1JCR | Crystal structure of rat protein farnesyltransferase complexed with the non-substrate tetrapeptide… | x-ray diffraction | B | — | — |
| 1JCR | Crystal structure of rat protein farnesyltransferase complexed with the non-substrate tetrapeptide… | x-ray diffraction | B | — | — |
| 1JCS | Crystal structure of rat protein farnesyltransferase complexed with the peptide substrate tkcvfm… | x-ray diffraction | B | — | — |
| 1JCS | Crystal structure of rat protein farnesyltransferase complexed with the peptide substrate tkcvfm… | x-ray diffraction | B | — | — |
| 1KZO | Protein farnesyltransferase complexed with farnesylated K-RAS4B peptide product and farnesyl… | x-ray diffraction | B | — | — |
| 1KZO | Protein farnesyltransferase complexed with farnesylated K-RAS4B peptide product and farnesyl… | x-ray diffraction | B | — | — |
| 1KZP | Protein farnesyltransferase complexed with a farnesylated K-RAS4B peptide product | x-ray diffraction | B | — | — |
| 1KZP | Protein farnesyltransferase complexed with a farnesylated K-RAS4B peptide product | x-ray diffraction | B | — | — |
| 1N94 | Aryl Tetrahydropyridine Inhbitors of Farnesyltransferase: Glycine, Phenylalanine and Histidine… | x-ray diffraction | B | — | — |
| 1N94 | Aryl tetrahydropyridine inhbitors of farnesyltransferase: glycine, phenylalanine and histidine… | x-ray diffraction | B | — | — |
| 1N95 | Aryl Tetrahydrophyridine Inhbitors of Farnesyltranferase: Glycine, Phenylalanine and Histidine… | x-ray diffraction | B | — | — |
| 1N95 | Aryl tetrahydrophyridine inhbitors of farnesyltranferase: glycine, phenylalanine and histidine… | x-ray diffraction | B | — | — |
| 1N9A | Farnesyltransferase complex with tetrahydropyridine inhibitors | x-ray diffraction | B | — | — |
| 1N9A | Farnesyltransferase complex with tetrahydropyridine inhibitors | x-ray diffraction | B | — | — |
| 1NI1 | Imidazole and cyanophenyl farnesyl transferase inhibitors | x-ray diffraction | B | — | — |
| 1NI1 | Imidazole and cyanophenyl farnesyl transferase inhibitors | x-ray diffraction | B | — | — |
| 1NL4 | Crystal Structure of Rat Farnesyl Transferase in Complex With A Potent Biphenyl Inhibitor | x-ray diffraction | B | — | — |
| 1NL4 | Crystal structure of rat farnesyl transferase in complex with a potent biphenyl inhibitor | x-ray diffraction | B | — | — |
| 1O1R | Structure of FPT bound to GGPP | x-ray diffraction | B | — | — |
| 1O1R | Structure of fpt bound to ggpp | x-ray diffraction | B | — | — |
| 1O1S | Structure of FPT bound to isoprenoid analog 3b | x-ray diffraction | B | — | — |
| 1O1S | Structure of fpt bound to isoprenoid analog 3B | x-ray diffraction | B | — | — |
| 1O1T | Structure of FPT bound to the CVIM-FPP product | x-ray diffraction | B | — | — |
| 1O1T | Structure of fpt bound to the cvim-fpp product | x-ray diffraction | B | — | — |
| 1O5M | Structure of FPT bound to the inhibitor SCH66336 | x-ray diffraction | B | — | — |
| 1O5M | Structure of fpt bound to the inhibitor SCH66336 | x-ray diffraction | B | — | — |
| 1QBQ | Structure of rat farnesyl protein transferase complexed with a cvim peptide and… | x-ray diffraction | B | — | — |
| 1QBQ | Structure of rat farnesyl protein transferase complexed with a cvim peptide and… | x-ray diffraction | B | — | — |
| 1SA5 | Rat protein farnesyltransferase complexed with FPP and BMS-214662 | x-ray diffraction | B | — | — |
| 1SA5 | Rat protein farnesyltransferase complexed with fpp and bms- 214662 | x-ray diffraction | B | — | — |
| 1TN7 | Protein Farnesyltransferase Complexed with a TC21 Peptide Substrate and a FPP Analog at 2.3A… | x-ray diffraction | B | — | — |
| 1TN7 | Protein farnesyltransferase complexed with a TC21 peptide substrate and a fpp analog at 2.3A… | x-ray diffraction | B | — | — |
| 1TN8 | Protein Farnesyltransferase Complexed with a H-Ras Peptide Substrate and a FPP Analog at 2.25A… | x-ray diffraction | B | — | — |
| 1TN8 | Protein farnesyltransferase complexed with a H-RAS peptide substrate and a fpp analog at 2.25A… | x-ray diffraction | B | — | — |
| 1X81 | Farnesyl transferase structure of Jansen compound | x-ray diffraction | B | — | — |
| 1X81 | Farnesyl transferase structure of jansen compound | x-ray diffraction | B | — | — |
| 2BED | Structure of FPT bound to inhibitor SCH207736 | x-ray diffraction | B | — | — |
| 2BED | Structure of fpt bound to inhibitor SCH207736 | x-ray diffraction | B | — | — |
| 2R2L | Structure of Farnesyl Protein Transferase bound to PB-93 | x-ray diffraction | B | — | — |
| 2R2L | Structure of farnesyl protein transferase bound to pb-93 | x-ray diffraction | B | — | — |
| 2ZIR | Crystal Structure of rat protein farnesyltransferase complexed with a benzofuran inhibitor and FPP | x-ray diffraction | B | — | — |
| 2ZIR | Crystal structure of rat protein farnesyltransferase complexed with a benzofuran inhibitor and fpp | x-ray diffraction | B | — | — |
| 2ZIS | Crystal Structure of rat protein farnesyltransferase complexed with a bezoruran inhibitor and FPP | x-ray diffraction | B | — | — |
| 2ZIS | Crystal structure of rat protein farnesyltransferase complexed with a bezoruran inhibitor and fpp | x-ray diffraction | B | — | — |
| 3DPY | Protein farnesyltransferase complexed with FPP and caged TKCVIM substrate | x-ray diffraction | B | — | — |
| 3DPY | Protein farnesyltransferase complexed with fpp and caged tkcvim substrate | x-ray diffraction | B | — | — |
| 3E30 | Protein farnesyltransferase complexed with FPP and ethylene diamine inhibitor 4 | x-ray diffraction | B | — | — |
| 3E30 | Protein farnesyltransferase complexed with fpp and ethylene diamine inhibitor 4 | x-ray diffraction | B | — | — |
| 3E32 | Protein farnesyltransferase complexed with FPP and ethylenediamine scaffold inhibitor 2 | x-ray diffraction | B | — | — |
| 3E32 | Protein farnesyltransferase complexed with fpp and ethylenediamine scaffold inhibitor 2 | x-ray diffraction | B | — | — |
30 records more on the page itself.
Ligands
- ZN · Zinc ion · in 5 records
- 60I · [4-[[3-(2,2-dimethylpropyl)-1~{H}-benzimidazol-2-yl]methyl]piperazin-1-yl]-(1,3,5-trimethylpyrazol-4-yl)methanone · in 4 records
- MG · Magnesium ion · in 4 records
- ACE · Acetyl group · in 3 records
- DMA · Dimethylallyl diphosphate · in 2 records
- PPV · Pyrophosphate · in 2 records
- FPP · Farnesyl diphosphate · in 1 record
- XMY · (5S)-4-({1-[(4-bromophenyl)methyl]-1H-imidazol-5-yl}methyl)-5-butyl-1-[3-(trifluoromethoxy)phenyl]piperazin-2-one · in 1 record
Experiment against prediction
- 3EU5 chain B against the predicted model Q02293: TM-score 0.99, RMSD 0.69 Å
- 3EU5 chain B against the predicted model Q02293: TM-score 0.99, RMSD 0.69 Å
- 3EUV chain B against the predicted model Q02293: TM-score 0.99, RMSD 0.67 Å
- 3EUV chain B against the predicted model Q02293: TM-score 0.99, RMSD 0.67 Å
- 1FT2 chain B against the predicted model Q02293: TM-score 0.99, RMSD 0.81 Å
- 1FT2 chain B against the predicted model Q02293: TM-score 0.99, RMSD 0.81 Å
- 2BED chain B against the predicted model Q02293: TM-score 0.99, RMSD 0.86 Å
- 2BED chain B against the predicted model Q02293: TM-score 0.99, RMSD 0.86 Å
- 2ZIS chain B against the predicted model Q02293: TM-score 0.99, RMSD 0.90 Å
- 2ZIS chain B against the predicted model Q02293: TM-score 0.99, RMSD 0.90 Å
Elsewhere
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