MolNFT v1 · #6868 · protein
Protein farnesyltransferase complex with farnesyl diphosphate
1FPP: “Protein farnesyltransferase complex with farnesyl diphosphate”. X-ray diffraction, 3 ligands (FPP, ZN, PO4), 14 pockets (best druggability 0.82). MolNFT v1 #6868 on GenesisL1: 3D structure, binding sites and pockets in GL1X.
- PDB
- 1FPP
- Type
- protein
- Length
- 716 residues
- Chains
- 2
- Method
- x-ray diffraction
- Collection
- MolNFT v1 / PDB
- Contract
- 0xDE3723766Bc32dcACD03C17BaA400A7B36837Eba
- Owner
- 0x3396CDB397284571d12822B4ae1189a8E22AAAAA
- Molecule
- Protein farnesyltransferase
- EC
- 2.5.1.-
- UniProt
- Q02293, Q04631
- Ligands
- FPP, ZN, PO4
- Pockets
- 14 · best druggability 0.82
Structure
x-ray diffraction · 2 distinct chains · 58% helix, 3% strand (DSSP).
| Chain | Molecule | Type | Residues | Secondary structure | UniProt |
|---|---|---|---|---|---|
| B | Protein farnesyltransferase (EC 2.5.1.-) | protein | 400 | 51% helix, 5% strand | Q02293 |
| A | Protein farnesyltransferase (EC 2.5.1.-) | protein | 316 | 68% helix, 1% strand | Q04631 |
Ligands and binding sites
- FPP · Farnesyl diphosphate · ligand · chains B
- ZN · Zinc ion · metal · chains B
- PO4 · Phosphate ion · ion · chains B, A
Binding sites are the residues within 4.5 Å of a ligand's heavy atoms.
Pockets
14 pockets found on a 1 Å grid, 2 with a druggability of 0.5 or more.
| Volume (ų) | Druggability | Buriedness | Lining residues | Inside | |
|---|---|---|---|---|---|
| 1 | 279 | 0.82 | 0.93 | 48 | empty |
| 2 | 1026 | 0.77 | 0.79 | 69 | FPP |
| 3 | 58 | 0.50 | 0.86 | 17 | empty |
| 4 | 170 | 0.49 | 0.77 | 31 | empty |
| 5 | 147 | 0.47 | 0.77 | 21 | empty |
Interfaces
1 interface between chains.
- B–A · 3503 Ų buried · 76 hydrogen bonds · protein-protein
Compared structures
- 1FPP · Protein farnesyltransferase complex with farnesyl diphosphate · the same entry in another collection · chain B against B, TM-score 1.00
- Q04631 · AlphaFold monomer V2.0 prediction for protein FARNESYLTRANSFERASE/GERANYLGERANYLTRANSFERAS… · a predicted model of the same protein · chain A against A, TM-score 0.99
- Q02293 · AlphaFold monomer V2.0 prediction for protein farnesyltransferase subunit beta (Q02293) · a predicted model of the same protein · chain B against A, TM-score 0.99
Analyse
- Open in the research workbench: secondary structure, accessibility, pockets, interfaces, conservation, variants, modifications, peptides and crosslinks on the 3D structure
- Every structure of UniProt Q02293
- Every structure of UniProt Q04631
- Elsewhere: RCSB PDB 1FPP · PDBe 1FPP · UniProt Q02293 · UniProt Q04631
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